Abstract:A universal and robust strategy using polyurethane sponge as a precursor was developed to synthesize highly-soluble nitrogen-doped carbon quantum dots via a solvothermal method.
“…As a result, zebrafish provides a solid foundation for assessing the toxicity of tested compounds/materials [ 69 ]; [ 70 ]. The purpose of the toxicity test is to determine whether the synthesized PCDs are suitable for bioimaging applications and to see if utilising them as a bioimaging probe has any potentially harmful side effects [ 71 ]. Interestingly, the prepared PCDs did not show any significant mortality to zebrafish larvae up to 500 µg/mL concentration (Fig.…”
Photoluminescent nanomaterials have been widely employed in several biological applications both in vitro and in vivo. For the first time, we report a novel application of sour apple-derived photoluminescent carbon dots (PCDs) for reducing ultra-high molecular weight polyethylene (UHMWPE) wear particle-induced osteolysis using mouse calvarial model. Generally, aseptic prosthetic loosening seems to be a significant postoperative problem for artificial joints replacement, which is mainly contributed by UHMWPE-induced osteolysis. Hence, inhibiting osteoclastic bone-resorption could minimize UHMWPE-induced osteolysis for implant loosening. Prior to osteolysis studies, the prepared sour apple-derived PCDs were employed for bioimaging application. As expected, the prepared PCDs effectively inhibited the UHMWPE particle-induced osteoclastogenesis in vitro. The PCDs treatment effectively inhibited the UHMWPE-induced osteoclast differentiation, F-actin ring pattern, and bone resorption in vitro. Also, the PCDs reduced the UHMWPE-induced ROS stress as well as the expression level of pro-inflammatory cytokines, including TNF-α, IL-1, IL-6, and IL-8. Further, the qPCR and western blot results hypothesized that PCDs inhibited the UHMWPE wear particle-induced osteolysis through suppressing chemerin/ChemR23 signaling and NFATc1 pathway, along with upregulation of SIRT1 expression. Overall, these findings suggest that the synthesized PCDs could be a potential therapeutic material for minimizing UHMWPE particle-induced periprosthetic osteolysis to avoid postoperative complications.
“…As a result, zebrafish provides a solid foundation for assessing the toxicity of tested compounds/materials [ 69 ]; [ 70 ]. The purpose of the toxicity test is to determine whether the synthesized PCDs are suitable for bioimaging applications and to see if utilising them as a bioimaging probe has any potentially harmful side effects [ 71 ]. Interestingly, the prepared PCDs did not show any significant mortality to zebrafish larvae up to 500 µg/mL concentration (Fig.…”
Photoluminescent nanomaterials have been widely employed in several biological applications both in vitro and in vivo. For the first time, we report a novel application of sour apple-derived photoluminescent carbon dots (PCDs) for reducing ultra-high molecular weight polyethylene (UHMWPE) wear particle-induced osteolysis using mouse calvarial model. Generally, aseptic prosthetic loosening seems to be a significant postoperative problem for artificial joints replacement, which is mainly contributed by UHMWPE-induced osteolysis. Hence, inhibiting osteoclastic bone-resorption could minimize UHMWPE-induced osteolysis for implant loosening. Prior to osteolysis studies, the prepared sour apple-derived PCDs were employed for bioimaging application. As expected, the prepared PCDs effectively inhibited the UHMWPE particle-induced osteoclastogenesis in vitro. The PCDs treatment effectively inhibited the UHMWPE-induced osteoclast differentiation, F-actin ring pattern, and bone resorption in vitro. Also, the PCDs reduced the UHMWPE-induced ROS stress as well as the expression level of pro-inflammatory cytokines, including TNF-α, IL-1, IL-6, and IL-8. Further, the qPCR and western blot results hypothesized that PCDs inhibited the UHMWPE wear particle-induced osteolysis through suppressing chemerin/ChemR23 signaling and NFATc1 pathway, along with upregulation of SIRT1 expression. Overall, these findings suggest that the synthesized PCDs could be a potential therapeutic material for minimizing UHMWPE particle-induced periprosthetic osteolysis to avoid postoperative complications.
“…The second and third peaks at 400.8 and 401.5 eV reflect the bonding structure of the N–H and C–N–C bonds. 16–23 The deconvolution of the O 1s region shows three peaks at 530.95, 531.6, and 532.6 eV (Fig. 3d).…”
Section: Resultsmentioning
confidence: 95%
“…18,27,45,46 The high-resolution XPS spectrum of N 1s shows three peaks centred at 399.5, 400.8 and 401.5 eV The second and third peaks at 400.8 and 401.5 eV reect the bonding structure of the N-H and C-N-C bonds. [16][17][18][19][20][21][22][23] The deconvolution of the O 1s region shows three peaks at 530.95, 531.6, and 532.6 eV (Fig. 3d).…”
Section: Characterization Of Neo-cdsmentioning
confidence: 99%
“…Doping heteroatoms such as nitrogen and phosphorous into CDs leads to changes in their electronic properties and may create more active sites. [18][19][20][21][22][23][24][25] Thus, heteroatom doped CDs have been extensively synthesized to improve their electronic properties, quantum yield and photostability.…”
The first-ever neomycin antibiotic-based carbon dots (Neo-CDs) were synthesized via low-cost, eco-friendly, and a single-step hydrothermal method using neomycin as a single precursor. The as-prepared Neo-CDs exhibited strong and stable...
“…9 With the development of UV blocking materials, carbon nanodots (CNDs) have gradually been used to block high-energy short wavelength light due to their excellent optical absorption and conversion properties. 1,2,10,11 CNDs are a new type of carbon nanomaterial with a particle size <10 nm, excellent resistance to photobleaching and good responsiveness to changes in pH and temperature, [12][13][14][15][16] which are widely used in white light emitting diodes (WLEDs), [17][18][19][20] in anticounterfeiting applications, 21,22 as probes, [23][24][25] and catalysts, 26,27 and for biological imaging. 28,29 Among the many possible sources of carbon for preparing carbon dots, natural resources and derivatives are particularly attractive because of their abundance, low price, environmental friendliness and sustainability.…”
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