Synthesis of polydopamine as a new and biocompatible coating of magnetic nanoparticles for delivery of doxorubicin in mouse breast adenocarcinoma

Zavareh, Saeed; Mahdi, Milad; Erfanian, Soheyla; Hashemi‐Moghaddam, Hamid

doi:10.1007/s00280-016-3169-5

Cited by 37 publications

(27 citation statements)

References 62 publications

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“…However, the employment of MMIPs as carriers of anticancer agents is emerging. Only a few publications reported the development of MMIPs with the aim of smart delivery of anticancer drugs local to the tumor [ 3 , 50 , 54 , 61 , 65 , 68 , 77 , 78 , 79 , 80 , 81 ] that shed light on the development of a novel generation of multifunctional hybrid DDSs and future perspectives in this field.…”

Section: State Of the Artmentioning

confidence: 99%

“…5-FU, DOX and EPI with a broad antineoplastic spectrum are used to treat many different types of cancer as colon or rectum, breast, liver, bladder and brain [ 50 , 61 , 79 , 80 ]. The main drawbacks of direct chemotherapy with these agents can be listed as severe depression of hematopoiesis (anemia, leucopenia, thrombopenia), infection and cardiotoxicity regarding EPI [ 50 ], 5-FU resistance and rapid clearance from the body [ 6 ] and DOX cumulative cardiotoxicity and nephrotoxicity [ 82 ].…”

Section: State Of the Artmentioning

confidence: 99%

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Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Sanadgol

Wackerlig

2020

Pharmaceutics

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Cancer therapy is still a huge challenge, as especially chemotherapy shows several drawbacks like low specificity to tumor cells, rapid elimination of drugs, high toxicity and lack of aqueous solubility. The combination of molecular imprinting technology with magnetic nanoparticles provides a new class of smart hybrids, i.e., magnetic molecularly imprinted polymers (MMIPs) to overcome limitations in current cancer therapy. The application of these complexes is gaining more interest in therapy, due to their favorable properties, namely, the ability to be guided and to generate slight hyperthermia with an appropriate external magnetic field, alongside the high selectivity and loading capacity of imprinted polymers toward a template molecule. In cancer therapy, using the MMIPs as smart-drug-delivery robots can be a promising alternative to conventional direct administered chemotherapy, aiming to enhance drug accumulation/penetration into the tumors while fewer side effects on the other organs. Overview: In this review, we state the necessity of further studies to translate the anticancer drug-delivery systems into clinical applications with high efficiency. This work relates to the latest state of MMIPs as smart-drug-delivery systems aiming to be used in chemotherapy. The application of computational modeling toward selecting the optimum imprinting interaction partners is stated. The preparation methods employed in these works are summarized and their attainment in drug-loading capacity, release behavior and cytotoxicity toward cancer cells in the manner of in vitro and in vivo studies are stated. As an essential issue toward the development of a body-friendly system, the biocompatibility and toxicity of the developed drug-delivery systems are discussed. We conclude with the promising perspectives in this emerging field. Areas covered: Last ten years of publications (till June 2020) in magnetic molecularly imprinted polymeric nanoparticles for application as smart-drug-delivery systems in chemotherapy.

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Section: State Of the Artmentioning

confidence: 99%

Section: State Of the Artmentioning

confidence: 99%

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Sanadgol

Wackerlig

2020

Pharmaceutics

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“…DOX [93,103] and 5-FU [64] PDA-based imprinted polymers were used to coat magnetic and silica NPs. The imprinted polymers showed a fast release of DOX and 5-FU, as 80% of template drug was released from the NPs within 4 h, with a maximum release after 24 h [64,93,103]. One important advantage of MIP-based PDA preparation is however, the use of mild alkaline aqueous media, which allows the synthesis of water-compatible MIPs.…”

Section: Biocompatibility and Biodegradability Of Mip-ddsmentioning

confidence: 99%

“…Magnetic NPs are frequently used for DDS development intended for cancer treatment, because they can be easily tracked, manipulated, and directed towards tumor site using external magnetic field. Iron oxide NPs are the only approved types of magnetic NPs for biomedical applications [107], magnetite being one of the naturally occurring iron oxides in human heart, liver, and spleen [103]. However, for in vivo applications their surface needs to be coated with biocompatible materials, since it was shown that they can induce severe toxicity via protein denaturation [108].…”

Section: Biocompatibility and Biodegradability Of Mip-ddsmentioning

confidence: 99%

“…However, for in vivo applications their surface needs to be coated with biocompatible materials, since it was shown that they can induce severe toxicity via protein denaturation [108]. PDA-coated magnetic NPs were synthesized for DOX [103] and 5-FU [64] imprinting. The resulting NPs showed good biocompatibility and their aggregation and oxidation was inhibited by the PDA-based MIP coating.…”

Section: Biocompatibility and Biodegradability Of Mip-ddsmentioning

confidence: 99%

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Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

2019

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Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics' release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.Polymers 2019, 11, 2085 2 of 33 normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.Polymers 2019, 11, x FOR PEER REVIEW 2 of 34 of both normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.

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Molecularly Imprinted Nanoparticles for Biomedical Applications

2019

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Molecularly imprinted polymers (MIPs) are synthetic receptors with tailor‐made recognition sites for target molecules. Their high affinity and selectivity, excellent stability, easy preparation, and low cost make them promising substitutes to biological receptors in many applications where molecular recognition is important. In particular, spherical MIP nanoparticles (or nanoMIPs) with diameters typically below 200 nm have drawn great attention because of their high surface‐area‐to‐volume ratio, easy removal of templates, rapid binding kinetics, good dispersion and handling ability, undemanding functionalization and surface modification, and their high compatibility with various nanodevices and in vivo biomedical applications. Recent years have witnessed significant progress made in the preparation of advanced functional nanoMIPs, which has eventually led to the rapid expansion of the MIP applications from the traditional separation and catalysis fields to the burgeoning biomedical areas. Here, a comprehensive overview of key recent advances made in the preparation of nanoMIPs and their important biomedical applications (including immunoassays, drug delivery, bioimaging, and biomimetic nanomedicine) is presented. The pros and cons of each synthetic strategy for nanoMIPs and their biomedical applications are discussed and the present challenges and future perspectives of the biomedical applications of nanoMIPs are also highlighted.

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Synthesis of polydopamine as a new and biocompatible coating of magnetic nanoparticles for delivery of doxorubicin in mouse breast adenocarcinoma

Abstract: Magnetic DOX-IP demonstrates effective tumor-targeted drug delivery in a mouse model of breast cancer.

Cited by 37 publications

References 62 publications

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

Molecularly Imprinted Nanoparticles for Biomedical Applications

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