Synthesis of poly(vinyl acetate–methyl methacrylate) copolymer microspheres using suspension polymerization

Islam, Md. Shahidul; Yeum, Jeong Hyun; Das, Ajoy Kumar

doi:10.1016/j.jcis.2011.11.002

Cited by 46 publications

(23 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5. The average sizes of the obtained hybrid hydrogel particles were similar to those of polymer microspheres prepared by conventional suspension polymerization [39,40] but were larger than those prepared using a membrane filter. [41] Further tuning of particle size and distribution would be possible by using up-to-date particulation methods such as emulsion and spraying.…”

Section: Preparation Of Hybrid Hydrogel Particles and Their Propertiesmentioning

confidence: 54%

Microspherical hydrogel particles based on silica nanoparticle-webbed polymer networks

Takafuji

Alam

Goto

et al. 2015

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

Section: Preparation Of Hybrid Hydrogel Particles and Their Propertiesmentioning

confidence: 54%

Microspherical hydrogel particles based on silica nanoparticle-webbed polymer networks

Takafuji

Alam

Goto

et al. 2015

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

“…This type of polymer is much stable and falls in degradable or non-degradable type [40]. Free-radical polymerization is carried out in the presence of an initiator and heat.…”

Section: Free-radical Polymerizationmentioning

confidence: 99%

Effect of Chemical Crosslinking on Properties of Polymer Microbeads: A Review

Mane¹,

Ponrathnam²,

Chavan³

2016

Can Chem Trans

View full text Add to dashboard Cite

Cross-link property has been used to improve the insolubility, mechanical strength, stiffness, and rigidity of polymer microbeads having potential applications in solid-phase synthesis, solid-phase extraction, and biomedical fields. Therefore synthesis of polymer with desired cross-linker (hydrophilic/hydrophobic/rigid/flexible) and concentration of cross-linker (cross-link density) is an important. In the present review, chemical cross-linking by free-radical, condensation, UV radiation, and small-molecule cross-linking are discussed in details. Further, effects of cross-linker (type/concentration) on polymer properties like surface area, pore volume, pore size, particle size, thermal degradation, glass transition temperature, and polymer swelling are also discussed. Importantly, present review discusses the influences of rigidity, flexibility, hydrophilicity, and hydrophobicity of a cross-linker on polymer properties.

show abstract

“…Dispersion is promoted through the combination of vigorous agitation and use of small quantities of stabilizers or suspending agents in order to maintain the hydrodynamic stability of the heterogeneous system, avoiding agglomeration of the suspended droplets. Polymerization takes place inside the monomer droplets, which are progressively converted into viscous and sticky granules, and finally become rigid polymer particles with characteristic sizes ranging from 50 to 500 µm . If the process is well controlled, the final obtained polymer powder presents the form of spherical beads that are easy to manipulate and separate through filtration …”

Section: Introductionmentioning

confidence: 99%

In Situ Incorporation of Praziquantel in Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Paiva

Vieira

Melo

et al. 2018

Macro Reaction Engineering

View full text Add to dashboard Cite

Schistosomiasis is one of the major public health problems worldwide. Even though this is a common illness among preschool children in poor countries, treatment is carried out mainly through the administration of praziquantel tablets, which has some disadvantages, such as the strong bitter taste. As an alternative to overcome this problem, the development of new encapsulated praziquantel formulations is demanded. For this reason, suspension polymerizations are carried out for the in situ encapsulation of praziquantel into polymer microparticles, using methyl methacrylate (MMA) and cationic compounds (diethylaminoethyl methacrylate, DEAEMA, and dimethylaminoethyl methacrylate, DMAEMA) as comonomers. This technique allows for the preparation of polymer microparticles with high encapsulation efficiencies (>90%) with characteristic sizes ranging from 0.5 to 1500 µm. Drug release profiles show that praziquantel is released from poly(methyl methacrylate) microparticles slowly due to the existence of strong diffusional resistance. On the other hand, the addition of cationic comonomers renders polymer particles sensitive to pH variations, allowing for faster release of praziquantel in acidic environments, as found in the stomach.

show abstract

Synthesis of poly(vinyl acetate–methyl methacrylate) copolymer microspheres using suspension polymerization

Cited by 46 publications

References 38 publications

Microspherical hydrogel particles based on silica nanoparticle-webbed polymer networks

Microspherical hydrogel particles based on silica nanoparticle-webbed polymer networks

Effect of Chemical Crosslinking on Properties of Polymer Microbeads: A Review

In Situ Incorporation of Praziquantel in Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Contact Info

Product

Resources

About