Synthesis of poly-O-sulfated glycosides of 2,5-anhydro-d-mannitol

The goal of research evaluation is to reveal the achievement and progress of research. Research output offers a basis for empirical evaluation. A fair and just research evaluation should take into account the diversity of research output across disciplines and include all major forms of research publications. This article reviews the literature on the nature of research output in social sciences and humanities in terms of the characteristics of research publications, and then discusses the implications for the research evaluation of social sciences and humanities researchers.

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“…10 was prepared using known procedures 66. A solution of 10 (3.09 g, 8.29 mmol) in dry CH 2 Cl 2 (50 ml) was cooled down to 0°C.…”

Section: Methodsmentioning

confidence: 99%

Characteristics of research output in social sciences and humanities: From a research evaluation perspective

Huang

Chang

2008

J. Am. Soc. Inf. Sci.

152

126

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“…The chromatographic separation of this product yielded 135 mg of hexa-O-acetyl-D-mannitol. The identification of the D-mannitol and its acetylated derivative was achieved by comparison of its spectral and physical data with those in literature [ 15 , 16 ].…”

Section: Resultsmentioning

confidence: 99%

“…Hexa-O-acetyl-D-mannitol was isolated from the fractions eluted with 9 : 1, hexane : EtOAc. The identity of the acetate derivate was achieved by comparison of its spectroscopic and spectrometric data with those reported in the literature [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

The Hypocholesterolemic Effects of Eryngium carlinae F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8

Castro-Torres

O-Arciniega

Naranjo‐Rodríguez

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Hypercholesterolemia is a metabolic disorder characterized by a high concentration of cholesterol in the blood. Eryngium carlinae is a medicinal plant used to treat lipid diseases. The goal of this work was to evaluate, in a model of hypercholesterolemia in mice, the hypocholesterolemic effect of a hydroalcoholic extract of E. carlinae and its main metabolite, D-mannitol. Biochemical analyses of serum lipids and hepatic enzymes were performed by photocolorimetry. We performed histopathological studies of the liver and the expression of the intestinal cholesterol transporters Abcg5 and Abcg8 was determined by standard western blot method. Our results showed that hydroalcoholic extract at doses of 100 mg/kg and D-mannitol at doses of 10 mg/kg reduced the concentration of both total cholesterol and non-HDL cholesterol, without altering the concentration of HDL cholesterol and without damage to hepatocytes. Treatment with the extract increased Abcg8 intestinal transporter expression, while D-mannitol decreased the expression of the two Abcg5/Abcg8 transporters, compared with the hypercholesterolemic group. Considering that Abcg5/Abcg8 transporters perform cholesterol efflux, our results demonstrate that the lipid-lowering effect of the hydroalcoholic extract may be associated with the increase of Abcg8 expression, but the hypocholesterolemic effect of D-mannitol is independent of overexpression of these intestinal transporters and probably they have another mechanism of action.

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“…Sulfated saccharides play an important role in nature. They are an integral part of heparan‐sulfate, a linear glycosaminoglycan, which is well known as an anticoagulant . On the other hand, low molecular weight heparin showed both anticoagulant and antithrombotic activity .…”

Section: Introductionmentioning

confidence: 99%

Novel 1‐O‐Sulfono‐α‐d‐Fructofuranosyl Sulfones as Possible Inhibitors of Human GnT‐I Enzyme

et al. 2020

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The present work is dedicated to Professor Ladislav Petruš on the occasion of his 70th birthday.Library of a new class of C-1 monosulfated saccharide derivatives derived from D-fructofuranose have been synthesized as potential GnT-I inhibitors. To increase stability of originally proposed thioglycosides, the compounds were oxi-dized to sulfones bearing three different aglycons; ethyl, 2methyl propyl (isopropyl) and phenyl. Here we present molecular modelling, synthesis and biological assays of prepared compounds. Scheme 2. Reagent and Conditions: a) TBDMSCl, pyridine, À 20°C!r.t., overnight; b) DMTrCl, DMAP, pyridine, r.t. overnight; c) 1 M TBAF in THF, THF, r.t., 90 min; d) BnBr, DMF, NaH, 0°C!r.t., 2 h; e) CF 3 COOH, DCM, triethylsilane, r.t., 1.5-4 h. Scheme 3. Reagent and Conditions: a) SO 3 ⋅py complex, DCM, r.t., 48 h; b) 3chloroperbenzoic acid, DCM, 0°C!r.t., 0.5-1.5 h. Scheme 4. Reagent and Conditions: a) SO 3 .py complex, DCM, r.t., 48 h; b) cat. 10 % Pd/C, H 2 , MeOH, 2 h.

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Synthesis of poly-O-sulfated glycosides of 2,5-anhydro-d-mannitol

Cited by 8 publications

References 14 publications

Characteristics of research output in social sciences and humanities: From a research evaluation perspective

Characteristics of research output in social sciences and humanities: From a research evaluation perspective

The Hypocholesterolemic Effects of Eryngium carlinae F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8

Novel 1‐O‐Sulfono‐α‐d‐Fructofuranosyl Sulfones as Possible Inhibitors of Human GnT‐I Enzyme

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