Synthesis of Poly(methacrylic acid-co-butyl acrylate) Grafted onto Functionalized Carbon Nanotube Nanocomposites for Drug Delivery

Abstract

Design of a smart drug delivery system is a topic of current interest. Under this perspective, polymer nanocomposites (PNs) of butyl acrylate (BA), methacrylic acid (MAA), and functionalized carbon nanotubes (CNTsf) were synthesized by in situ emulsion polymerization (IEP). Carbon nanotubes were synthesized by chemical vapor deposition (CVD) and purified with steam. Purified CNTs were analyzed by FE-SEM and HR-TEM. CNTsf contain acyl chloride groups attached to their surface. Purified and functionalized CNTs were studied by FT-IR and Raman spectroscopies. The synthesized nanocomposites were studied by XPS, 13C-NMR, and DSC. Anhydride groups link CNTsf to MAA–BA polymeric chains. The potentiality of the prepared nanocomposites, and of their pure polymer matrices to deliver hydrocortisone, was evaluated in vitro by UV–VIS spectroscopy. The relationship between the chemical structure of the synthesized nanocomposites, or their pure polymeric matrices, and their ability to release hydrocortisone was studied by FT-IR spectroscopy. The hydrocortisone release profile of some of the studied nanocomposites is driven by a change in the inter-associated to self-associated hydrogen bonds balance. The CNTsf used to prepare the studied nanocomposites act as hydrocortisone reservoirs.

A pH responsive and superporous biocomposite hydrogel of Salvia spinosa polysaccharide-co-methacrylic acid for intelligent drug delivery

“…The value of n appears in the range from 0.553 to 0.817 determined through the Korsmeyer–Peppas model indicating that the venlafaxine HCl release followed the non-Fickian diffusion. 30,31…”

“…A signal at 944 cm −1 due to vinyl linkage (C]C-H) can also be seen in its spectrum. 30 Aer conversion, a broadband at 2987 cm −1 in the spectrum of MAA is not present in the spectrum of SSH-co-MAA, it is because of conversion of unsaturated pi-bond of MAA to saturated sigma-bond aer the copolymerization. Likewise, the spectrum of MAA contains a peak at 944 cm −1 while the same peak in the spectrum of MAA became weaker and slightly shied to a lower wavenumber, i.e., 937 cm −1 .…”

“…The value of n appears in the range from 0.553 to 0.817 determined through the Korsmeyer-Peppas model indicating that the venlafaxine HCl release followed the non-Fickian diffusion. 30,31 SSH-co-MAA hydrogels are composed of polymeric backbones with ionic pendant groups (COOH group in MAA). In aqueous media of pertinent pH, the pendant groups ionize and produce xed charges on the polymer network, creating electrostatic repulsive forces responsible for pH-dependent swelling thereby controlling the drug release.…”

Polymer Adsorbents vs. Functionalized Oxides and Carbons: Particulate Morphology and Textural and SurfaceCharacteristics

“…Therefore, a set of methods could be used in parallel, such as direct (TEM, SEM) and indirect (probe adsorption, SAXS, NMR cryoporometry, DSC thermoporometry, etc.) methods [9,28,31,[54][55][56][64][65][66][74][75][76][77][78][79][80][81][82][83][84][85][86][87]111,[114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130]. More accurate results can be obtained if several methods are used in parallel (e.g., SAXS and adsorption).…”

Acrylate and Methacrylate Polymers’ Applications: Second Life with Inexpensive and Sustainable Recycling Approaches

“…Josué A. Torres-Ávalos reported the synthesis of poly(methacrylic acid-co-butyl acrylate) grafted onto functionalized carbon nanotube (CNTs). The authors evidenced that both the presence of CNTs and the change in the inter-associated to self-associated hydrogen bonds balance strongly influence the hydrocortisone release [ 77 ].…”