Synthesis Of Poly(acrylamide-co-[2-acryloyloxy Ethyl]trimethyl Ammonium Chloride) Star-shaped Polymers By Inverse Microemulsion Polymerization

Katime, Issa; Álvarez–Bautista, Arturo; Mendizábal, Eduardo; Guerrero-Ramírez, Luis-Guillermo; Ochoa-Gómez, José R.

doi:10.5185/amlett.2012.6377

Cited by 4 publications

(8 citation statements)

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“…Furthermore, FT-IR spectra reveal that increasing the mass ratio of mixed charges gives rise to novel absorption bands at 949, 1033, and 1727 cm −1 , attributed to TMA functional group, 34 SO 3 − stretch, and the carbonyl group composing both TMA and SA monomers. 22,34 The gradual increase of intensity of these three absorption bands with TMA and SA content is another indication of effective and wellcontrolled gel formation process.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Furthermore, FT-IR spectra reveal that increasing the mass ratio of mixed charges gives rise to novel absorption bands at 949 cm -1 , 1033 cm -1 and 1727 cm -1 , attributed to TMA 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 functional group, 34 SO 3 -stretch and the carbonyl group composing both TMA and SA monomers. 22,34 The gradual increase of intensity of these three absorption bands with TMA and SA content is another indication of effective and well-controlled gel formation process. Swelling behavior of hydrogels was studied in different conditions of temperature, ionic strength and pH.…”

Section: Characterization Of Hydrogels -Influence Of Environmental Stmentioning

confidence: 98%

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Stimuli-Responsive and Hemocompatible Pseudozwitterionic Interfaces

et al. 2015

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We report a novel biomacromolecular formula for the design of hemocompatible gel interfaces of N-isopropylacrylamide (NIPAAm) and mixed-charge pairs of [2-(methacryloyloxy)ethyl]trimethylammonium (TMA) and 3-sulfopropyl methacrylate (SA) with overall electrical neutrality. The study stresses on how well-defined compositions of nonionic NIPAAm and pseudozwitterionic TMA/SA in the poly(NIPAAm-co-TMA/SA) hydrogels along with environmental conditions (temperature, ionic strength, and solution pH) affect swelling and adhesion of biofoulants on their surfaces. When challenged with plasma proteins, bacteria, recalcified platelets, or whole blood, stimuli-responsive hydrogels better resisted their adhesion as the content of mixed charges in the copolymer increased, to reach nonbiofouling for the gels made of 100% TMA/SA. The low hemolytic activity (0.5%) associated with a long plasma clotting time (10 min) suggests excellent hemocompatibility excellent hemocompatibility. Finally, hydrogels containing both NIPAAm and TMA/SA tend to exhibit preferential adhesion of leukocytes.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Characterization Of Hydrogels -Influence Of Environmental Stmentioning

confidence: 98%

Stimuli-Responsive and Hemocompatible Pseudozwitterionic Interfaces

et al. 2015

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“…Nine samples were dispersed in an aqueous acid medium (pH 5.5), and the other nine were dispersed in an aqueous basic medium (pH 7.4). The samples were shaken and maintained in dispersion for different time periods (0, 5,10,15,20,25,30,35, and 40 min, respectively). After the specified contact time, the supernatant is collected…”

Section: Release Kinetics Of Terfenadine By Uv-vismentioning

confidence: 99%

“…In particular, functionalized pH-sensitive nanohydrogels have already shown suitable properties regarding their applicability in cancer treatment. [1][2] Due to the functionalization of the nanoparticles with folic acid [3][4][5][6][7], they can target the malign cells (folic receptors that can be found in many carcinogenic cells) and cross the cytoplasmic barrier through an endocytosis process mediated by a receptor. Due to their response to lower pH, once the nanoparticles are inside the cell, they will swell and release the drug carried inside, just in the place it is required.…”

Section: Introductionmentioning

confidence: 99%

Controlled delivery of drugs through smart pH-sensitive nanohydrogels for anti-cancer therapies: synthesis, drug release and cellular studies

Álvarez–Bautista

Duarte

Mendizábal

et al. 2016

Designed Monomers and Polymers

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Nanohydrogels were synthesized by microemulsion polymerization. These nanohydrogels were pre-designed to be pH and temperature stimuli-response materials, using N-isopropylacrilamide as a base monomer and 1-vinyl imidazole as ionizable comonomer. The pH sensitivity was confirmed by measuring the increase or decrease in volume in the nanoparticles by changing the pH of the medium. Nanoparticles were properly characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR) and transmission electron microscopy (TEM). Glass-transition temperature increased with vinyl imidazole content, and nanoparticles with average diameter of 68 nm were obtained. Particle size decreases with the increase in pH. After characterization, nanohydrogels were functionalized with folic acid to take advantage that the folate receptor is overexpressed in different types of cancer cells. The nanoparticles were loaded with the drugs: metformin, terfenadine, and 5-fluorouracil. The amount of drug loaded and released by nanoparticles was measured by UV-vis spectroscopy. Then, cellular viability and internalization studies were performed obtaining promising results.

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“…For copolymer P(DAC-AM) and its closely related homopolymer PDAC, the study of their thermal decomposition started at the end of the 20th century [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. Since 2006, although the cationicity and [ η ] of the polymerization products P(DAC-AM) reported were different, the thermal stability characterized by the thermodynamic parameters were only for individual samples and even the further mechanism study had not been reported, until recently.…”

Section: Introductionmentioning

confidence: 99%

Thermal Decomposition Mechanism of P(DAC-AM) with Serial Cationicity and Intrinsic Viscosity

Chen,

Wang,

Zhang

2024

Polymers

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The thermal decomposition of the thermodynamic, kinetic and mechanisms of copolymer P(DAC-AM) samples with serial cationicity and intrinsic viscosity ([η]), and the control samples of homopolymer PAM and PDAC, were studied and analyzed using TG, DSC, FTIR. The results of the thermal decomposition thermodynamics confirmed that the thermal decomposition processes of the serial P(DAC-AM) samples and the two control samples could be divided into two stages. It was found that the processes of the copolymer P(DAC-AM) samples were not a simple superposition of those of homopolymers, whose monomers had composed the unit structures of the copolymer, but there were interactions between the two suspension groups. The results of thermal decomposition kinetics showed that the apparent activation energy (E) of the thermal decomposition process of all polymer samples had different varying trends in the terms of weight-loss rate (α). The reaction order (n) of the thermal decomposition of P(DAC-AM) in Stage I and II was close to 1, but in the former and the latter it tended to be 2 and 0.5, respectively. Finally, the thermal decomposition mechanism of copolymer P(DAC-AM) samples was discussed. The above research could not only fill in the knowledge vacancy of the thermal decomposition of the thermodynamic, kinetic and mechanisms of P(DAC-AM), but could also lay a foundation for the study of thermal decomposition mechanisms of the other types of polymers, including cationic polymers.

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Synthesis Of Poly(acrylamide-co-[2-acryloyloxy Ethyl]trimethyl Ammonium Chloride) Star-shaped Polymers By Inverse Microemulsion Polymerization

Cited by 4 publications

References 0 publications

Stimuli-Responsive and Hemocompatible Pseudozwitterionic Interfaces

Stimuli-Responsive and Hemocompatible Pseudozwitterionic Interfaces

Controlled delivery of drugs through smart pH-sensitive nanohydrogels for anti-cancer therapies: synthesis, drug release and cellular studies

Thermal Decomposition Mechanism of P(DAC-AM) with Serial Cationicity and Intrinsic Viscosity

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