Synthesis of poly(1,2-glycerol carbonate)–paclitaxel conjugates and their utility as a single high-dose replacement for multi-dose treatment regimens in peritoneal cancer

Abstract

A high drug-density, biodegradable polymeric nanocarrier replaces multi-dose paclitaxel treatment regimens.

Carbon dioxide copolymers: Emerging sustainable materials for versatile applications

“…Different from other aliphatic polycarbonates, the degradation rate of poly (1,2‐glycerol carbonate) was fast, which could be completely degraded into its monomer and hydroxyl‐containing components with half degradation time ( t 1/2 ) of 2‐3 days 124 . The functional aliphatic polycarbonate containing hydroxyl group showed certain potential in biomedical materials such as drug release and tissue engineering 42 . Interestingly, Grinstaff and coworkers developed sustainable polycarbonate adhesives by terpolymerization of PO/glycidyl butyrate/CO 2 , which exhibited competitive adhesion ability in comparison with nondegradable commercial adhesives such as Scotch‐tape ® 125 …”

“…Noteworthily, these epoxides usually contain additional functional groups, such as alkene, offering enormous opportunities for postpolymerization modification 38 . The functionalized polycarbonates are endowed with tailor‐made properties, including amphiphilicity, 39 self‐healing, 40 biocompatibility, 41 enabling more specialized applications such as drug delivery, 42 adhesives, 43 ion detection, 44 and so forth. Among the bioderived epoxides, the copolymerization of LO and CO 2 has received broader studies including catalyst screening, crystalline behavior of the copolymer, scale‐up synthesis, and material performance tests for both parent and postmodulated polycarbonates 45–49 .…”

Poly(Alkyl Glycidate Carbonate)s as Degradable Pressure‐Sensitive Adhesives

“…Polymers incorporating a glycerol backbone are of significant interest owing to their degradability, biocompatibility, and chemical tunability . Glycerol is listed as “generally recognized as safe” (GRAS) by the Food and Drug Administration, and as such, linear, branched, hyperbranched, and dendritic polyglycerols are being investigated for a wide‐variety of medical and non‐medical use …”

Chemical Design of Both a Glutathione-Sensitive Dimeric Drug Guest and a Glucose-Derived Nanocarrier Host to Achieve Enhanced Osteosarcoma Lung Metastatic Anticancer Selectivity

“…Nanoparticles derived from biodegradable polymers, such as polyesters, polypeptides, PPEs, ,, and polycarbonates, , have gained increasing interest for nanomedicines, which reduce the potential for long-term accumulation and associated adverse effects. Recently, our group employed functional glucose-derived polycarbonates (PGCs) to construct nanostructures with tunable sizes, surface charges, and morphologies that are, notably, capable of degradation into natural products, for example, glucose, carbon dioxide, and ethanol. , We expected that leveraging the PGC-derived nanostructures as nanocarriers would circumvent potential drawbacks of our previous PPE system, namely, the production of ethylene glycol and phosphoric acid upon hydrolytic degradation, while maintaining the advantages of degradability, biocompatibility, and versatile functionality, such as for dye-labeling .…”