Synthesis of Plant Mediated gold Nanoparticles using Azima Tetracantha Lam. Leaves extract and Evaluation of their Antimicrobial Activities

Hariharan, Abirami; Begum, Tajuddin Nargis; Ilyas, Mohamed Hussain Muhammad; Jahangir, Hussain Syed; Premkumar, Kumpati; Mathew, Shilu; Archunan, ‪Govindaraju; Qadri, Ishtiaq

doi:10.5530/pj.2016.5.17

Cited by 14 publications

(6 citation statements)

References 18 publications

(20 reference statements)

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“…The AuNPs showed maximum activity against S. typhimurium and minimum activity against M. luteus amongst bacterial pathogens while among fungi they were effective against T. rubrum with minimal smaller effect in Cryptococcus sp. A clear concentration effect was found[34]. Nagalingam et al[24] reported efficient antibacterial activity of AuNPs synthesised using A. bettzickiana leaf extract against B. subtilis, S. aureus, S. typhi, P. aeroginosa, M. luteus, and E. aerogenes by agar well diffusion method.…”

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Antimicrobial, antioxidant and anticancer activities of gold nanoparticles green synthesized using Mangifera indica seed aqueous extract

Donga

Bhadu

Chanda

2020

Artificial Cells, Nanomedicine, and Biotechnology

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In this study, gold nanoparticles (AuNPs) were synthesised using seed extract of mango (Mangifera indica) which is considered as waste and generally thrown away into the environment. The bioactive molecules in the seed act as reducing agent to synthesise AuNPs without using any external agent. The characterisation of green synthesised AuNPs was done using various spectroscopic techniques. Visual colour change from colourless to ruby red colour confirmed the formation of AuNPs which was further confirmed by maximum absorption peak at 550 nm by UV-spectra. Crystalline nature was confirmed by XRD technique while round, triangle and irregular shape and 19.45 nm size was confirmed by TEM and SAED analysis. FTIR analysis confirmed the presence of alcohol or phenol, carboxylic acid, ketones, amines, aromatic amines, aliphatic amines, alkyl halides and alkynes in M. indica seed which were responsible for the reduction of gold to AuNPs. The green synthesised AuNPs were evaluated for their antimicrobial, antioxidant and cytotoxic potential. They showed moderate antibacterial, cytotoxic and dose-dependent antioxidant activity. Seeds of M. indica instead of discarding can be successfully utilised for AuNPs synthesis which can be used as a natural source of antimicrobial, antioxidant and anticancer agent. HIGHLIGHTS Green synthesis of gold nanoparticles (AuNPs) from fruit (Mangifera indica) waste (seed). Characterisation using various spectroscopic techniques: UV-Vis spectroscopy, Zeta potential, FTIR, XRD and TEM analysis. Synthesized AuNPs were round, triangle and irregular in shape and 19.45 nm in size. Antimicrobial activity of AuNPs against 14 microorganisms. Antioxidant activity of AuNPs in terms of DPPH, SO and ABTS. Cytotoxic activity against HeLa, MCF-7 and fibroblast normal cell lines.

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confidence: 99%

Antimicrobial, antioxidant and anticancer activities of gold nanoparticles green synthesized using Mangifera indica seed aqueous extract

Donga

Bhadu

Chanda

2020

Artificial Cells, Nanomedicine, and Biotechnology

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“…The nanoparticles were effective against both larvae to more or less similar extent. Hariharan et al [111] synthesized gold nanoparticles using aqueous extract of A. tetracantha leaves. The synthesized nanoparticles were evaluated for antimicrobial activity against bacteria, yeasts and dermatophytes.…”

Section: Bioactivities Of Nanoparticles Synthesized Using a Tetracanthamentioning

confidence: 99%

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Raghavendra¹

2017

IJGP

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Plants form an integral part of daily life of human beings. The term ethnobotany refers to relationships and interactions between people and plants. Worldwide, plants are being used as sources of food, medicine, dyes, and timber. Traditional medicinal practitioners and indigenous systems of medicine (such as Ayurveda, Siddha and Unani) make use of several plant species to treat a range of ailments of humans and livestock. The therapeutic potential of plants lies in the presence of secondary metabolites such as alkaloids, terpenes, and polyphenolic compounds. Azima tetracantha Lam., belonging to the family Salvadoraceae, is a small, armed shrub with quadrangular branches. The present review is a compilation of available data on the ethnomedicinal uses, phytochemistry, and pharmacological activities of A. tetracantha. Phytochemical investigations on the plant revealed the presence of chemicals such friedelin, euphanol, gallic acid, genstisic acid, cinnamate, ferulic acid, azimine, azcarpine, and carpaine. An extensive literature survey was carried out to compile data on traditional uses, phytochemicals, and the pharmacological activities shown by A. tetracantha. It is evident from the literatures that the plant is versatile with respect to its traditional uses as a remedy for various illnesses and disorders in humans and animals. The plant is used for treatment of asthma, cold, cough, rheumatism, diabetes, dysentery, fever, toothache, dog bite, snake bite, and liver diseases. It is experimentally shown that the plant exhibits pharmacological activities such as antimicrobial, antioxidant, anti-inflammatory, cytotoxic, antivenom, hepatoprotective, antiepileptic, diuretic, antiulcer, antiasthmatic, antidiarrheal, analgesic, nephroprotective, antipyretic, and insecticidal activity. The nanoparticles synthesized from A. tetracantha have shown antimicrobial, antioxidant, and insecticidal properties. A pentacyclic triterpenoid friedelin isolated from the plant is shown to exhibit many bioactivities such as antimicrobial, hypolipidemic, antidiarrheal, anti-inflammatory, antipyretic, insecticidal, gastroprotective and antiradical activity. The therapeutic potential and pharmacological properties of A. tetracantha could be ascribed to the presence of a wide array of phytochemicals in it. The pharmacological activities of the plant reported justify the traditional use of A. tetracantha in treating several diseases or disorders.

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“…Previous finding suggested that the absorbance range for Au-NPs is 500-600 nm. In a reported study on biosynthesis of Au-NPs using Azimat etracantha leave extract showed absorbance band was between 535-550 nm [18] . Similarly Au-NPs were prepared with the help of Azadirachta indica (Neem) leaf extract, which showed absorbance peak at 560nm [19] .…”

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“…The extract of this plant was used in biliousness [9] . A decoction of leaves is given once in a day as kidney stone treatment [10] .…”

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Green Synthesis and Antibacterial Activity of Gold Nanoparticles of Digera muricata

Shah¹,

Shah²,

Shah³

et al. 2020

pharmaceutical-sciences

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Shah et al.: Green Synthesis of Gold Nanoparticles of Digera muricata The current research work was about a suitable eco-friendly process to produce gold nanoparticles using ethanol extract of Digera muricata. Completion of synthesis, size and morphology of nanoparticles and various functional groups present were confirmed using various techniques. Formation and physical appearance of gold nanoparticles was confirmed through the presence of dark purple colour. Ultraviolet/ Vis spectra give a sharp narrow peak at the λmax specified for gold nanoparticle. Scanning electron microscopy indicated nanoparticles were spherical in shape, fully dispersed in reaction medium with 40±5 nm size. X-ray diffraction analysis revealed that synthesized nanoparticles were crystalline with an average particle size of 33 nm. The presence of bio-organic compound was detected by Fourier-transform infrared spectroscopy. Antibacterial potential of the synthesized gold nanoparticles of Digera muricata extract was evaluated in comparison to crude ethanol extract. The gold nanoparticles exhibited greater antibacterial potential as compared to crude ethanol extract of Digera muricata against different drug-resistant bacteria including Vibrio cholera, Staphylococcus pyrogen, Klebsiella, Citrobacter and Enterobacter. The results indicated that the gold nanoparticles could be used as a promising antibacterial agents

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Synthesis of Plant Mediated gold Nanoparticles using Azima Tetracantha Lam. Leaves extract and Evaluation of their Antimicrobial Activities

Cited by 14 publications

References 18 publications

Antimicrobial, antioxidant and anticancer activities of gold nanoparticles green synthesized using Mangifera indica seed aqueous extract

Antimicrobial, antioxidant and anticancer activities of gold nanoparticles green synthesized using Mangifera indica seed aqueous extract

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Green Synthesis and Antibacterial Activity of Gold Nanoparticles of Digera muricata

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