Synthesis of photoresponsive hybrid alginate hydrogel with photo-controlled release behavior

Design, Synthesis, Investigation, and Application of a Macromolecule Photoswitch

“…Photo molecular switches can reversibly exhibit different properties due to their structural changes upon a light stimulus, making them new favorites in recent decades in fields that require switching effects, such as information science and chemical sensing (Sun et al, 2012; Yuan et al, 2014; Chiang and Chu, 2015; Kim et al, 2015; Bian et al, 2016a). Generally, photo switches possess a conjugated structure and precise spatiotemporal control such as chiral helicene, azobenzene, diarylethene, spiropyran, binaphthyl compounds (Beharry and Woolley, 2011; Sun et al, 2012; Yuan et al, 2014; Chiang and Chu, 2015; Kim et al, 2015; Bian et al, 2016a; Lubbe et al, 2017; Chen et al, 2018; Lerch et al, 2018). Among these molecules, azobenzene's have been intensively investigated on account of their flexible property (Chen et al, 2009, 2018; Schmidt et al, 2010; Beharry and Woolley, 2011; Li et al, 2014; Yuan et al, 2014; Deka et al, 2015; Bian et al, 2016a,b; Lin et al, 2016; Lubbe et al, 2017; Lerch et al, 2018).…”

Synthesis and Characterization of Photoresponsive Macromolecule for Biomedical Application

“…Consequently, azobenzenes became particularly popular as photoresponsive chromophores in a number of research fields including biomedical fields (Deka et al, 2015 ; Liu et al, 2015 ; Bian et al, 2016a , b ). Recently, on account of photo-controlled reversible supermolecular interaction between azobenzenes and cyclodextrins, hydrogels as well as films with controllable pores or passages crosslinked by the supermolecular interaction have been designed and synthesized to respond to photo-stimuli from external environment (Chen et al, 2009 ; Chiang and Chu, 2015 ; Wang et al, 2015 ). In addition to these reports, visible light driven azobenzene-based photo-switching molecules have been theoretically designed by different substitute groups (Pang et al, 2014 , 2016 ; Ye et al, 2015 ).…”

In Vitro/In Vivo Evaluation of Sustained Release of Glucagon-Like Peptide-1 (GLP-1) from Nanocomposite Hydrogel to Induce Angiogenesis

“…Therefore, the binding of proteins to alginate in order to enhance cell attachment of this material when it is used as a cell scaffold is favored by forming amide bonds [24,25]. Also, the ability of alginate to form a physical gel due to binding with divalent cations, such as calcium, makes it favorable in tissue engineering applications as an irreversible in situ formation of a gel [26]. In further steps, the system proposed in this study could be used as an injectable alginate gel which could be injected into heart muscle and release GLP-1 locally to increase drug bioavailability and effectiveness.…”