Synthesis of photoreactive pullulan for surface modification

Hasuda, Hirokazu; Kwon, Oh Hyeong; Kang, Inn‐Kyu; Ito, Yoshihiro

doi:10.1016/j.biomaterials.2004.07.065

Cited by 53 publications

(22 citation statements)

References 32 publications

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“…Pullulan being adhesive is also tried for wound dressing applications. The thermal stability and elastic properties of pullulan allow it to be utilized in many different ways [109,112,113].…”

Section: Pullulanmentioning

confidence: 99%

Natural Products: A Minefield of Biomaterials

Ige

Umoru

Aribo

2012

ISRN Materials Science

152

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The development of natural biomaterials is not regarded as a new area of science, but has existed for centuries. The use of natural products as a biomaterial is currently undergoing a renaissance in the biomedical field. The major limitations of natural biomaterials are due to the immunogenic response that can occur following implantation and the lot-to-lot variability in molecular structure associated with animal sourcing. The chemical stability and biocompatibility of natural products in the body greatly accounts for their utilization in recent times. The paper succinctly defines biomaterials in terms of natural products and also that natural products as materials in biomedical fields are considerably versatile and promising. The various types of natural products and forms of biomaterials are highlighted. Three main areas of applications of natural products as materials in medicine are described, namely, wound management products, drug delivery systems, and tissue engineering. This paper presents a brief history of natural products as biomaterials, various types of natural biomaterials, properties, demand and economic importance, and the area of application of natural biomaterials in recent times.

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Section: Pullulanmentioning

confidence: 99%

Natural Products: A Minefield of Biomaterials

Ige

Umoru

Aribo

2012

ISRN Materials Science

152

View full text Add to dashboard Cite

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“…As the hydrophobic surface was formed by solidification of FI-LMCs, it was considered that the interaction between solidified FI-LMCs and cell might be reduced. 21,22 Antiadhesive agent should act as a kind of barrier between tissues on the surgery region and keep separate the tissue from neighbor tissues. Therefore, less interaction of cell with the anti-adhesive agent is quite important to reduce side effects when it is used in the body.…”

Section: Structural Analysis By 1 H Nmr and Gpc Spectroscopicmentioning

confidence: 99%

Synthesis of visible light-induced cross-linkable chitosan as an anti-adhesive agent

Kim

Ito

et al. 2011

Macromol. Res.

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Visible light-induced cross-linkable chitosan was synthesized by the incorporation of furfuryl isocyanate. The synthesized chitosan derivative was analyzed by 1 H NMR and GPC. The synthesized chitosan derivative showed no significant toxicity. The synthesized chitosan derivative was mixed with Rose Bengal in distilled water and irradiated with visible light for 5 min in the presence of a photomask. A micropattern that matched the micropattern of photomask was formed and the photoreactivity of the synthesized chitosan derivative was confirmed. Solidification of the synthesized chitosan is believed to have occurred by a photo-oxidation-induced cross-linking mechanism. Contact angle measurements and cell culture on the surface of solidified chitosan derivative were also carried out. Cell adhesion on the surface of solidified chitosan was not shown. Considering these results, the synthesized chitosan derivative is non-cytotoxic, solidifies rapidly by visible light not chemicals, and has fewer cell interactions. The synthesized chitosan derivative is a novel candidate for anti-adhesive agent.

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“…Photocurable natural polymers have received a considerable amount of attention in the field of tissue engineering, biomaterial coating, and drug delivery mainly due to their mild crosslinking ability compared to other methods 17,18. Photocurable natural polymers can be used as matrices to immobilize various bioactive compounds such as HA, growth factors, drugs, proteins, and DNA 19–21…”

Section: Introductionmentioning

confidence: 99%

“…17,18 Photocurable natural polymers can be used as matrices to immobilize various bioactive compounds such as HA, growth factors, drugs, proteins, and DNA. [19][20][21] Chitosan was used as a base polymer in this study. A deacetylated form of chitin, chitosan is a natural polymer composed of 2amino-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-glucose units.…”

Section: Introductionmentioning

confidence: 99%

Coating of titanium plate by photocurable azidophenyl chitosan derivative for application to implants

Seo

Park

Lee

et al. 2012

J of Applied Polymer Sci

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Titanium (Ti) is widely used as an implant material. There are various kinds of Ti surface modification methods to facilitate effective osseointegration. In this study, UV‐curable azido‐LMC (azidophenyl low molecular weight chitosan) was used to modify the Ti surface. Here we suggest a novel Ti coating material that confers complex, diverse improvements to the Ti surface through a simple process. First, a cytotoxicity test of azido‐LMC against osteoblast MG‐63 was performed. The curing ratio dependent on UV irradiation time and concentration was determined by a comparison of weight. A 5% azido‐LMC solution, which showed a wide curing ratio range, was used to investigate the surface properties. The contact angle value was measured to compare hydrophilicity, and osteoblast MG‐63 cells were cultured on the coating surface. The Bradford assay was used to assess the protein immobilization capability. Hydroxyapatite, which has a beneficial influence on osseointegration, was included on the coating surface and observed by scanning electron microscopy. Surface roughness was measured by atomic force microscopy. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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Synthesis of photoreactive pullulan for surface modification

Cited by 53 publications

References 32 publications

Natural Products: A Minefield of Biomaterials

Natural Products: A Minefield of Biomaterials

Synthesis of visible light-induced cross-linkable chitosan as an anti-adhesive agent

Coating of titanium plate by photocurable azidophenyl chitosan derivative for application to implants

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