Synthesis of photoreactive -4-azidobenzoyl--methoxy-poly(ethylene glycol)s and their end-on photo-grafting onto polysulfone ultrafiltration membranes

Thom, Volkmar; Jankova, Katja; Ulbricht, Mathias; Kops, Jørgen; Jonsson, Gunnar Eigil

doi:10.1002/(sici)1521-3935(19981201)199:12<2723::aid-macp2723>3.3.co;2-b

Cited by 21 publications

(43 citation statements)

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“…Saito and coworkers have introduced various functional groups including iminodiacetate, amidooxime, phosphoric acid, alchohol hydroxyl, phenylalanine, and chlorovinylpyridine to polyethylene (PE) hollow fi bers by the radiation grafting of monomers such as glycidylmethacrylate (GMA) followed by specifi c chemical treatments [64 -69] . Affi nity membranes were also prepared by photochemical grafting [70,71] .…”

Section: Affi Nity Polymerssupporting

confidence: 90%

In Separation and Purification

Nasef

2008

Polymer Grafting and Crosslinking

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Section: Affi Nity Polymerssupporting

confidence: 90%

In Separation and Purification

Nasef

2008

Polymer Grafting and Crosslinking

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“…[22][23][24][25][26][27] The covalent grafting of PEG onto a variety of substrates, including silicon, 24,28 polyurethane-urea, 29 glass, 30,31 fluorinated ethylene-propylene copolymers, 32 and polysulfone membranes, 33 has been reported along with a quite satisfactory protein-repellent effect. It may be anticipated that the proteinrepellent properties of PEG would prevent an extracellular matrix from being formed and, thus, cells from adhering.…”

Section: Introductionmentioning

confidence: 99%

Improved Performances of Intraocular Lenses by Poly(ethylene glycol) Chemical Coatings

et al. 2007

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Cataract surgery is a routine ophthalmologic intervention resulting in replacement of the opacified natural lens by a polymeric intraocular lens (IOL). A main postoperative complication, as a result of protein adsorption and lens epithelial cell (LEC) adhesion, growth, and proliferation, is the secondary cataract, referred to as posterior capsular opacification (PCO). To avoid PCO formation, a poly(ethylene glycol) (PEG) chemical coating was created on the surface of hydrogel IOLs. Attenuated total reflectance Fourier transform infrared spectroscopy, “captive bubble” and “water droplet” contact angle measurements, and atomic force microscopy analyses proved the covalent grafting of the PEG chains on the IOL surface while keeping unchanged the optical properties of the initial material. A strong decrease of protein adsorption and cell adhesion depending on the molar mass of the grafted PEG (1100, 2000, and 5000 g/mol) was observed by performing the relevant in vitro tests with green fluorescent protein and LECs, respectively. Thus, the study provides a facile method for developing materials with nonfouling properties, particularly IOLs.

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“…[1] Polymer material surfaces can easily be modified with functional polymers under mild conditions using UV-irradiation excitation, via the ''grafting-from'' [2] and the ''grafting-to'' approach. [3] The flexibility, in particular with respect to wide variations of layer functionality and base polymer surface coverage, is much larger for the ''grafting-from'' techniques. Using a photoinitiator, e.g.…”

Section: Introductionmentioning

confidence: 99%

Photoreactive Functionalization of Poly(ethylene terephthalate) Track‐Etched Pore Surfaces with “Smart” Polymer Systems

Geismann

Ulbricht

2005

Macro Chemistry & Physics

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116

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Summary: Poly(ethylene terephthalate) (PET) track‐etched membranes with a pore diameter of ca. 700 nm, optionally surface‐functionalized to create a “carboxyl” or “amino” surface, were used for heterogeneous graft copolymerizations. Grafted poly(acrylic acid) acted as a pH responsive, “smart” polymer. To evaluate the surface‐specific initiation of graft copolymerizations unmodified and primary functionalized membranes were systematically combined with three differently charged benzophenone derivatives as photoinitiators, which were adsorbed on the PET surface prior to the reaction. The functionalized membranes thus obtained were characterized for chemical structure and permeability as a function of pH. The pore structure with a narrow size distribution and the resulting high sensitivity of the membrane permeability to the grafting functionalizations made the track‐etched PET membranes a very useful tool for analyzing structure and function of responsive grafted polymer layers. The primary functionalization of the base polymer with a molecular layer of a multifunctional alkylamine (“amino” surface) enhanced the efficiency of the subsequent graft copolymerization via photoinitiated hydrogen abstraction considerably because a high density of well accessible reactive groups had been introduced. The preadsorption of the photoinitiator on the base polymer surface was significantly improved by ionic interactions between the respective functional groups of the surface and the photoinitiator. Such a photoinitiator preadsorption, especially when combined with a reactive layer from the primary functionalization, enabled a very efficient and surface selective functionalization because a better control of grafting density and a reduction of photoinitiated side reactions along with a more efficient use of the photoinitiator were possible.Water permeabilities (pH 2 and pH 7) of unmodified and functionalized PET membranes for identification of optimal synthesis and evaluation conditions.magnified imageWater permeabilities (pH 2 and pH 7) of unmodified and functionalized PET membranes for identification of optimal synthesis and evaluation conditions.

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Synthesis of photoreactive -4-azidobenzoyl--methoxy-poly(ethylene glycol)s and their end-on photo-grafting onto polysulfone ultrafiltration membranes

Cited by 21 publications

References 0 publications

In Separation and Purification

In Separation and Purification

Improved Performances of Intraocular Lenses by Poly(ethylene glycol) Chemical Coatings

Photoreactive Functionalization of Poly(ethylene terephthalate) Track‐Etched Pore Surfaces with “Smart” Polymer Systems

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