“…Unsaturated archaetidic acid and its analogs (14, 14, 15, and 16) were synthesized from geranylgeraniol (1, for the systematic name, see Table III), phytol (2, Funakoshi), or oleyl alcohol (3, Kanto Chemical Co.) and either 1-O-benzyl-sn-glycerol (4) or 3-O-benzyl-sn-glycerol (4) (Funakoshi) as described (5,12,13). De-methylation conditions with trimethylsilyl bromide of 11, 11, 12, and 13 were modified to 0°C for 2 min because these compounds are labile under the original conditions (13). The final products (14, 14, 15, and 16), were purified by TLC using solvent A.…”