Synthesis of pH-, thermo- and salt-responsive hydrogels containing MCM-41 as crosslinker in situ for controlled drug release

Li, Yinhui; Li, Pengwei; Lu, Jingqiong; Zhao, Yangsheng

doi:10.1007/s00289-020-03325-x

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…Studies have shown that hydrogels that respond to external stimuli, such as pH‐sensitive hydrogels, have also been reported 86 87 and is also affected by other environmental factors, so the stimulation‐responsive hydrogels in the drug delivery system has attracted extensive attention.…”

Section: Products and Applicationsmentioning

confidence: 99%

Konjac glucomannan: A review of structure, physicochemical properties, and wound dressing applications

Zhou

Zheng

Xie

et al. 2021

J of Applied Polymer Sci

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Natural bio‐based materials used in wound dressings have been continuously developed in recent years, and have certain advantages in water retention, biocompatibility, and therapeutic properties. Konjac glucomannan (KGM) is a kind of plant polysaccharide with good cell compatibility and gel properties. Various gels obtained by modification of KGM through physical and chemical methods have great application potential in wound excipients. In the past few years, various KGM‐based wound barrier materials such as hydrogels, xerogel, microspheres, films, and fibers have been continuously researched and developed. The combination of KGM and other polymers can improve the problem of poor mechanical properties and give it new functional properties, which is beneficial to the moisturizing of the wound surface and the release of drugs to promote wound healing. This article reviews the physicochemical properties of KGM and the latest developments in KGM‐based composite gels, reveals the relationship between molecules in KGM‐based composite gels, and looks forward to the research and development prospects of KGM‐based composites in wound dressings.

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Section: Products and Applicationsmentioning

confidence: 99%

Konjac glucomannan: A review of structure, physicochemical properties, and wound dressing applications

Zhou

Zheng

Xie

et al. 2021

J of Applied Polymer Sci

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“…Cross-linking can be achieved either physically (e.g., heat treatment, freeze-thawing, radiation mediated) or chemically (i.e., the addition of a cross-linker). Different physical and chemical cross-linking methods have been examined in the past [ 34 , 35 , 36 ]. The two methodologies, as expected, have both advantages and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Mechanically Enhanced, Suturable, Fibrous Hydrogel Membranes

et al. 2023

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Poly(vinyl-alcohol) hydrogels have already been successfully utilised as drug carrier systems and tissue engineering scaffolds. However, lacking mechanical strength and suturability hinders any prospects for clinical and surgical applications. The objective of this work was to fabricate mechanically robust PVA membranes, which could also withstand surgical manipulation and suturing. Electrospun membranes and control hydrogels were produced with 61 kDa PVA. Using a high-speed rotating cylindrical collector, we achieved fibre alignment (fibre diameter: 300 ± 50 nm). Subsequently, we created multilayered samples with different orientations to achieve multidirectional reinforcement. Finally, utilising glutaraldehyde as a cross-linker, we created insoluble fibrous-hydrogel membranes. Mechanical studies were performed, confirming a fourfold increase in the specific loading capacities (from 0.21 to 0.84 Nm2/g) in the case of the monolayer samples. The multilayered membranes exhibited increased resistance from both horizontal and vertical directions, which varies according to the specific arrangement. Finally, the cross-linked fibrous hydrogel samples not only exhibited specific loading capacities significantly higher than their counterpart bulk hydrogels but successfully withstood suturing. Although cross-linking optimisation and animal experiments are required, these membranes have great prospects as alternatives to current surgical meshes, while the methodology could also be applied in other systems as well.

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“…3 Being an easily modifiable polymer (due to the imide-ring opening even under mild conditions) it has been exploited by researchers and utilized to produce for example thermal and pH reactive or magnetic nanoparticles incorporating systems. 1,4,5 PSI has been utilized in different forms (powder, gel, particles) [6][7][8] but the literature on nanofibrous membranes is very limited. Electrospinning is a fascinating method to fabricate meshes, membranes or scaffolds composed of nano-or micro-sized fibers.…”

Section: Introductionmentioning

confidence: 99%

“…Its production is fairly simple, as it only requires heat (as it is produced via thermal polycondensation), a catalyst (e.g., phosphoric acid) and the monomer itself ( l ‐aspartic acid) 3 . Being an easily modifiable polymer (due to the imide‐ring opening even under mild conditions) it has been exploited by researchers and utilized to produce for example thermal and pH reactive or magnetic nanoparticles incorporating systems 1,4,5 …”

Section: Introductionmentioning

confidence: 99%

Enhancing critical features of poly(amino acid) based meshes

Voniatis

Gottscháll

Barczikai

et al. 2021

J of Applied Polymer Sci

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The following manuscript presents a comprehensive investigation regarding the influence of electrospinning parameters on fiber quality and mechanical properties of nanofibrous poly(amino acid) meshes. At first, we examine parameters including: solvent options, polymer concentrations, collector speed and distance, voltage, needle sizes and flow rates to prepare fibrous scaffolds based on polysuccinimide. The main objective was to attempt and decrease the fiber diameter as much as possible while not reducing the fiber quality. After that mechanical properties of the meshes were investigated, we demonstrate two possible methods to reinforce them: mechanically induced alignment of the fibers and multilayer compression. Characterization methods include a solubility study, viscosity and conductivity measurements, ATR‐FTIR spectroscopy, scanning electron microscopy, and mechanical uniaxial test. Fiber size was successfully reduced from 615 to 280 nm without any quality aberrations. Mechanical performance not only improved almost three‐fold, but was also enhanced in two directions due to the multilayer composition. With these optimizations, the PSI mesh now possess favorable features for biomedical application according to the relevant literature.

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Synthesis of pH-, thermo- and salt-responsive hydrogels containing MCM-41 as crosslinker in situ for controlled drug release

Cited by 7 publications

References 32 publications

Konjac glucomannan: A review of structure, physicochemical properties, and wound dressing applications

Konjac glucomannan: A review of structure, physicochemical properties, and wound dressing applications

Fabrication of Mechanically Enhanced, Suturable, Fibrous Hydrogel Membranes

Enhancing critical features of poly(amino acid) based meshes

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