Synthesis of pH-sensitive poly (N,N-dimethylaminoethyl methacrylate)-grafted halloysite nanotubes for adsorption and controlled release of DPH and DS drugs

Hemmatpour, Hamoon; Haddadi‐Asl, Vahid; Roghani‐Mamaqani, Hossein

doi:10.1016/j.polymer.2015.03.067

Cited by 109 publications

(55 citation statements)

References 50 publications

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“…5a, survey scan spectrum of GO differs from FGO specially at the binding energies of 105.4 and 403.0 eV, which are, respectively, assigned to silicon and nitrogen atoms. The presence of Si 2p and N 1s bands in the spectrum of FGO confirms the successful covalent functionalization of GO by HDBTMSPU moieties [42,43]. As displayed in Fig.…”

Section: Resultssupporting

confidence: 65%

Incorporation of epoxy resin and graphene nanolayers into silica xerogel network: an insight into thermal improvement of resin

Najafi-Shoa

Roghani‐Mamaqani

Salami‐Kalajahi

2016

J Sol-Gel Sci Technol

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Three well-tuned procedures were used for thermal improvement of epoxy resin (E). Accordingly, graphene xerogel (GX) was used as nanofiller in the matrix of E. Additionally, (3-isocyanatopropyl)triethoxysilanemodified E (IE) or tetraethyl orthosilicate (TEOS) oligomer-modified E (TE) was incorporated into a hybrid structure of graphene-containing silica/siloxane network. For this purpose, a bifunctional silane coupling agent of 1,1 0 -(hexane-1,6-diyl)bis(3-(3-(trimethoxysilyl)propyl)urea) (HDBTMSPU) was synthesized. GX was obtained by incorporation of HDBTMSPU-modified graphene oxide (FGO) into xerogel structure using HDBTMSPU and TEOS. Modified resins, FGO, HDBTMSPU, and TEOS were also used in preparation of hybrid products. Thermal stability and char residue of the composites were compared. GO modification was approved by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, Raman, X-ray diffraction, and thermogravimetric analysis results. Hybrid composite of IE, FGO, and silica/siloxane network shows higher thermal properties. Char residue is increased by 16.93 % by loading of only 1 wt% of FGO in this hybrid product. Graphical Abstract

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Section: Resultssupporting

confidence: 65%

Incorporation of epoxy resin and graphene nanolayers into silica xerogel network: an insight into thermal improvement of resin

Najafi-Shoa

Roghani‐Mamaqani

Salami‐Kalajahi

2016

J Sol-Gel Sci Technol

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“…For the above mentioned reasons HNTs were functionalized with PDMAEMA and used as drug delivery systems for diphenhydramine hydrochloride and diclofenac sodium salt (Scheme 3). 77 HNT was functionalized with APTES by the classic silane coupling reaction. Then, a-bromoisobutyryl bromide (BiBB) was anchored to the amine groups by an acylation reaction to yield HNT-Br and, finally, initiator-anchored HNT was used as a precursor to attach PDMAEMA onto the HNT external surface (Scheme 3).…”

Section: Stimuli-responsive Carriersmentioning

confidence: 99%

Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications

et al. 2017

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a Halloysite (HNT) is a promising natural nanosized tubular clay mineral that has many important uses in different industrial fields. It is naturally occurring, biocompatible, and available in thousands of tons at low cost. As a consequence of a hollow cavity, HNT is mainly used as nanocontainer for the controlled release of several chemicals. Chemical modification of both surfaces (inner lumen and outer surface) is a strategy to tune the nanotube's properties. Specifically, chemical modification of HNT surfaces generates a nanoarchitecture with targeted affinity through outer surface functionalization and drug transport ability from functionalization of the nanotube lumen. The primary focus of this review is the research of modified halloysite nanotubes and their applications in biological and medical fields.

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“…This difference in the chemistry of inner and outer surface groups results in negatively charged exterior surface and positively charged interior surface in various pH values [3,4]. These unique features of HNTs result in their numerous applications in medicine, such as capturing flowing cells [5], bone implants [6], and drug delivery systems [7,8].…”

Section: Introductionmentioning

confidence: 99%

Nanofibers of poly (hydroxyethyl methacrylate)-grafted halloysite nanotubes and polycaprolactone by combination of RAFT polymerization and electrospinning

2015

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Halloysite nanotubes (HNTs) were functionalized with (3-Chloropropyl)triethoxysilane (CPTS) and sodium ethyl xanthate (NaEtX) to yield HNT-CPTS and HNT-RA respectively. Subsequently, HNT-RA was used as a substrate to graft poly (hydroxyethyl methacrylate) (PHEMA) to yield HNT-PHEMA. Then, HNT and polycaprolactone (PCL), HNT-PHEMA and PCL, and neat PCL in ethanol were electrospun. Successful grafting of CPTS, RA, and PHEMA on HNTs was evaluated by FTIR, TGA, and TEM. Stretching vibrations of C-H, C-O, and C=O bonds confirm the attachment of CPTS, NaEtX, and PHEMA respectively. Formation of PHEMA on the lumen, outer, and inner surface of HNTs is displayed by TEM. Cylindrical morphology of HNTs was revealed by SEM. DLS shows that grafting PHEMA at the surface of HNTs results in breaking of HNTs agglomerates. Surface roughness and morphology of nanofibers were evaluated by TEM. By surface grafting of HNTs with PHEMA, its dispersion in PCL is improved and HNTs removal from the nanofibers is reduced.

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Synthesis of pH-sensitive poly (N,N-dimethylaminoethyl methacrylate)-grafted halloysite nanotubes for adsorption and controlled release of DPH and DS drugs

Cited by 109 publications

References 50 publications

Incorporation of epoxy resin and graphene nanolayers into silica xerogel network: an insight into thermal improvement of resin

Incorporation of epoxy resin and graphene nanolayers into silica xerogel network: an insight into thermal improvement of resin

Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications

Nanofibers of poly (hydroxyethyl methacrylate)-grafted halloysite nanotubes and polycaprolactone by combination of RAFT polymerization and electrospinning

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