Synthesis of Passivating, Nylon-Like Coatings through Cross-Linking of Ultrathin Polyelectrolyte Films

Harris, Jeremy J.; DeRose, and Paul M.; Bruening, Merlin L.

doi:10.1021/ja9833467

Cited by 317 publications

(339 citation statements)

References 24 publications

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“…PLL molecules most probably get pushed out of the film. The film outside the affected area is not decomposed after light irradiation at a power above 20 mW (wavelength 830 nm) that could be due to temperature-mediated crosslinking between PLL and HA, as has been shown in literature at a temperature above 100 °C [110,111].…”

Section: Light-triggered Deliverysupporting

confidence: 56%

Polyelectrolyte Multilayers: Towards Single Cell Studies

2014

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Single cell analysis (SCA) is nowadays recognized as one of the key tools for diagnostics and fundamental cell biology studies. The Layer-by-layer (LbL) polyelectrolyte assembly is a rather new but powerful technique to produce multilayers. It allows to model the extracellular matrix in terms of its chemical and physical properties. Utilization of the multilayers for SCA may open new avenues in SCA because of the triple role of the multilayer film: (i) high capacity for various biomolecules; (ii) natural mimics of signal molecule diffusion to a cell and (iii) cell patterning opportunities. Besides, light-triggered release from multilayer films offers a way to deliver biomolecules with high spatio-temporal resolution. Here we review recent works showing strong potential to use multilayers for SCA and address accordingly the following issues: biomolecule loading, cell patterning, and light-triggered release.

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Section: Light-triggered Deliverysupporting

confidence: 56%

Polyelectrolyte Multilayers: Towards Single Cell Studies

2014

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“…Of the most popular, heat treatment was introduced in 1999 by Harris et al for covalently reticulation of PAHpoly(acrylic acid) (PAA) multilayers. 163 A biologically friendly approach using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)N-hydroxysuccinimide (NHS) crosslinkers has been also extensively studied during 2002 2003. 164166 This system has rapidly attracted the attention of the biomaterials research community since the elasticity of the substrate can be easily tuned.…”

Section: History Of Layer-by-layermentioning

confidence: 99%

Layer-by-layer Nanoarchitectonics: Invention, Innovation, and Evolution

et al. 2013

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Materials fabrication with nanoscale structural precision based on bottom-up-type self-assembly has become more important in various current disciplines in chemistry including materials chemistry, organic chemistry, physical chemistry, analytical chemistry, biochemistry, colloid and surface chemistry, and supramolecular chemistry. Although the design of new materials based on nanoscale self-assembly is anticipated as a key concept, preparing complete three-dimensional structures at nanoscale precision remains a difficult target using current technologies. Rather, dimension-reduced approaches such as layering of two-dimensional nanostructures into precisely controlled lamellar nanomaterials are currently achievable. In particular, layer-by-layer (LbL) assembly is known as a highly versatile method for fabrication of controlled layered structures from various kinds of component materials using very simple, inexpensive, and rapid procedures. Therefore, fabrication of multilayer films through the LbL deposition process has attracted growing interest from various research communities. The high versatility and flexibility of LbL assembly is continuously creating new concepts, new materials, new procedures, and new applications. In this highlight review, we focus on nanoarchitectonics by LbL assembly. After an initial introduction on the invention and a brief history of the LbL assembly technique, innovations and the evolution of the technique are described based mainly on recent examples, which are categorized into two sections: (i) developments in methodology (technical, material, and phenomenological aspects with expansion of concept) and (ii) progress in applications (physical, chemical/biochemical, and biomedical applications).

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“…The difference in peak-to-peak separation ΔE p suggests variation in film structure or charge. 23 The increase in the peak currents for films made with higher ionic strengths (samples 2 and 4) may suggest an increase in the permeability of the films due to increased porosity. The high permeability may be originated from a moderate delamination of films and less-stratified microstructure.…”

Section: Resultsmentioning

confidence: 98%

“…22 The estimation of parameters such as diffusion coefficient and electron transfer rate constant can explain the kinetics at interfaces, thus this technique becomes relatively easy and accurate as compared to other techniques. [23][24][25] In applying EIS for electrochemical system analysis, an important consideration is to fit experimental data to a suitable model. The use of EIS to study LbL films has become more common once LbL films find potential future in the field of bio-sensors and electrochemical sensors.…”

Section: Introductionmentioning

confidence: 99%

Ion Transfer in Layer-by-Layer Films

Wang¹,

Vyas²

2010

Polymer Thin Films

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The need for miniaturized devices has driven the exponential development of nanotechnology during the past two decades. One special field of paramount practical applications is electrochemical systems at the nano-scale. For successful development in such fields, an in-depth analysis of mass and/or charge transfer mechanism is highly desired. In such a system, mass transfer often takes the form of ion transfer, which can also be viewed as charge transfer. For example, in fuel cell development, the catalyst layer deposited on a polyelectrolyte membrane would demand higher ionic (protonic) conductivity. In the electrochemical sensors, the overall performance depends largely upon sensitivity of the thin films to recognize the analyte and the speed to communicate the resultant signals with the underlying electrodes. These phenomena are closely related to the (ionic) mass transfer within such films. A clear understanding of mass transfer in such an electrochemical system is the prerequisite for any significant progress in devices. Fundamentally, three different types of mass-transfer phenomena exists for ionic species in electrolytes at electrodes: (1) diffusional transport under concentration gradient, (2) migration transport of oppositely charged ions under electric field of the electrode, and (3) convection transport due to physical stirring of the electrolyte. For electrodes modified with electroactive or redox films, the redox behavior is much more complicated. When the applied potential reaches the oxidation potential of the redox-active species in the film, the electron transfer from the electrode surface to the film is coupled with the simultaneous ionic transfer from electrolyte to the film for maintaining electro-neutrality. Thus, we observe two simultaneous mass-transfer processes at the same time and each one needs to be characterized individually. A detailed study of mass-transfer within such films would first require conceptual understanding of the main characterization technique used. We will conduct a literature survey on various models used to characterize such mass transfer in layer-by-layer (LbL) films, and then propose a model for characterizing mass-transfer in LbL films that contain nanoparticles.

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Synthesis of Passivating, Nylon-Like Coatings through Cross-Linking of Ultrathin Polyelectrolyte Films

Cited by 317 publications

References 24 publications

Polyelectrolyte Multilayers: Towards Single Cell Studies

Polyelectrolyte Multilayers: Towards Single Cell Studies

Layer-by-layer Nanoarchitectonics: Invention, Innovation, and Evolution

Ion Transfer in Layer-by-Layer Films

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