Synthesis of Pashinintide A, a Natural Cyclic Hexapeptide Supposedly Capable of Forming a Complex with Sucrose

Abstract

Pashinintide A, a cyclic hexapeptide discovered from Pyrus pashia, has been synthesized in a linear sequence of 8 steps and 24% overall yield from N-Boc glycine, featuring a convergent [3 + 3] fragment coupling strategy. Although the structure of the synthetic Pashinintide A was unambiguously confirmed by X-ray diffraction analysis, its proposed complexation with sucrose cannot be validated.