Synthesis of Paralytic Shellfish Toxins: Saxitoxins

Approaches to Construction of the Medium-Sized Ring Structure in Zetekitoxin AB by Ring-Closing Metathesis

“…Synthetic studies of ZTX ( 1 ) have been reported by several groups . Nishikawa’s group and Looper’s group independently reported the synthesis of the isoxazolidine moiety in ZTX ( 1 ). , Du Bois’ group and Looper’s group developed strategies for C–C bond formation at C11 of ZTX ( 1 ), − aimed at the synthesis of the medium-sized ring structure of ZTX ( 1 ), although its construction has not yet been achieved.…”