Synthesis of PAMAM dendrimer-based fast cross-linking hydrogel for biofabrication

Bi, Xiangdong; Luckanagul, Jittima Amie; Allen, Ashley Nicole; Ramaboli, Matsepo C.; Campbell, Emily L.; West, Davey; Maturavongsadit, Panita; Brummett, Katelyn; Wang, Qian

doi:10.1080/09205063.2015.1056716

Cited by 27 publications

(17 citation statements)

References 53 publications

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“…Among the various types of polymeric NPs, dendrimer, a synthetic polymeric macromolecule of nanometer dimensions, are particularly fascinating, due to its unparalleled molecular uniformity, narrow molecular weight distribution, defined size and shape characteristics, highly branched structure, available internal cavity as well as a multifunctional terminal surface. These physicochemical characteristics of dendrimers, especially the multitude of functional groups on their periphery and abundant cavities within their interior, lead to higher reactivity and loading efficiency compared to the linear polymers, which make these macromolecules appropriate candidates for drug delivery [ 417 , 454 , 455 ]. Dendritic nanoparticles can also be incorporated into the hydrogel network via covalent or non-covalent interactions between dendrimers and the polymeric chains to obtain reinforced nanocomposite hydrogels with specific performance.…”

Section: Composites Of Hydrogels and Nanoparticlesmentioning

confidence: 99%

Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications

et al. 2015

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Due to their unique structures and properties, three-dimensional hydrogels and nanostructured particles have been widely studied and shown a very high potential for medical, therapeutic and diagnostic applications. However, hydrogels and nanoparticulate systems have respective disadvantages that limit their widespread applications. Recently, the incorporation of nanostructured fillers into hydrogels has been developed as an innovative means for the creation of novel materials with diverse functionality in order to meet new challenges. In this review, the fundamentals of hydrogels and nanoparticles (NPs) were briefly discussed, and then we comprehensively summarized recent advances in the design, synthesis, functionalization and application of nanocomposite hydrogels with enhanced mechanical, biological and physicochemical properties. Moreover, the current challenges and future opportunities for the use of these promising materials in the biomedical sector, especially the nanocomposite hydrogels produced from hydrogels and polymeric NPs, are discussed.

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Section: Composites Of Hydrogels and Nanoparticlesmentioning

confidence: 99%

Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications

et al. 2015

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“…However, synthetic materials tend to elicit more foreign body response (e.g., fibrous encapsulation) than natural polymers and generally require chemical modification with integrin-binding motifs or other cell adhesion molecules in order to promote favorable cell attachment, migration, and/or proliferation. 9, 10, 11, 12, 13 …”

Section: Introductionmentioning

confidence: 99%

Tunable Keratin Hydrogels for Controlled Erosion and Growth Factor Delivery

et al. 2015

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Tunable erosion of polymeric materials is an important aspect of tissue engineering for reasons that include cell infiltration, controlled release of therapeutic agents, and ultimately to tissue healing. In general, the biological response to proteinaceous polymeric hydrogels is favorable (e.g., minimal inflammatory response). However, unlike synthetic polymers, achieving tunable erosion with natural materials is a challenge. Keratins are a class of intermediate filament proteins that can be obtained from several sources including human hair and have gained increasing levels of use in tissue engineering applications. An important characteristic of keratin proteins is the presence of a large number of cysteine residues. Two classes of keratins with different chemical properties can be obtained by varying the extraction techniques: (1) keratose by oxidative extraction and (2) kerateine by reductive extraction. Cysteine residues of keratose are “capped” by sulfonic acid and are unable to form covalent crosslinks upon hydration, whereas cysteine residues of kerateine remain as sulfhydryl groups and spontaneously form covalent disulfide crosslinks. Here, we describe a straightforward approach to fabricate keratin hydrogels with tunable rates of erosion by mixing keratose and kerateine. SEM imaging and mechanical testing of freeze-dried materials showed similar pore diameters and compressive moduli, respectively, for each keratose-kerateine mixture formulation (~1200 kPa for freeze-dried materials and ~1.5 kPa for hydrogels). However, the elastic modulus (G’) determined by rheology varied in proportion with the keratose-kerateine ratios, as did the rate of hydrogel erosion and the release rate of thiol from the hydrogels. The variation in keratose-kerateine ratios also led to tunable control over release rates of recombinant human insulin-like growth factor 1.

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“…A rapid hydrogel formation was accomplished using a thiol-ene reaction between a poly(amido amine) (PAMAM) dendrimer containing vinyl sulfone groups on its periphery and thiolated hyaluronic acid by Wang and co-workers for biofabrication applications [26]. A generation 5 (G5) PAMAM dendrimer possessing 75 acetyl and the 35 residual amine groups were reacted with Traut’s reagent to obtain thiol functional groups.…”

Section: Fabrication Of Hydrogels Using Dendrimers and Dendrons Asmentioning

confidence: 99%

Dendrimers and Dendrons as Versatile Building Blocks for the Fabrication of Functional Hydrogels

et al. 2016

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Hydrogels have emerged as a versatile class of polymeric materials with a wide range of applications in biomedical sciences. The judicious choice of hydrogel precursors allows one to introduce the necessary attributes to these materials that dictate their performance towards intended applications. Traditionally, hydrogels were fabricated using either polymerization of monomers or through crosslinking of polymers. In recent years, dendrimers and dendrons have been employed as well-defined building blocks in these materials. The multivalent and multifunctional nature of dendritic constructs offers advantages in either formulation or the physical and chemical properties of the obtained hydrogels. This review highlights various approaches utilized for the fabrication of hydrogels using well-defined dendrimers, dendrons and their polymeric conjugates. Examples from recent literature are chosen to illustrate the wide variety of hydrogels that have been designed using dendrimer-and dendron-based building blocks for applications, such as sensing, drug delivery and tissue engineering.

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Synthesis of PAMAM dendrimer-based fast cross-linking hydrogel for biofabrication

Cited by 27 publications

References 53 publications

Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications

Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications

Tunable Keratin Hydrogels for Controlled Erosion and Growth Factor Delivery

Dendrimers and Dendrons as Versatile Building Blocks for the Fabrication of Functional Hydrogels

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