Synthesis of organoarsenic, organoantimony, and organobismuth poly(ether esters) from reaction with glycyrrhetinic acid and their preliminary activity against pancreatic cancer cell lines

Metallocene-containing polyesters from reaction of 3,5-pyridinedicarboxylic acid and metallocene dihalides and their preliminary ability to inhibit cancer cell growth

“…[6,76,82,89,90] More recently, we found that Group VA-containing polymers also exhibit some inhibition of pancreatic cancer cell lines. [91] The two most widely employed pancreatic cancer-associated cell lines are employed here. The cell lines tested are AsPC-1 which is an adenocarcinoma pancreatic cell line and PANC-1 which is an epithelioid carcinoma pancreatic cell line.…”

Creation of anticancer drugs employing metal-containing macromolecules

“…An additional comment, the EC values are calculated from a plot of concentration verses amount inhibited. Once inhibition begins, there is a rapid decrease in the curve ending at total inhibition [44][45][46][47][48].…”

Current and Potential Applications of Bismuth-Based Drugs

“…Carraher, Jr. and coworkers are interested in the development of biomedically or biologically active Group VA metal-containing polymers [122]. Recent example of this work describe organoarsenic, oraganoantimony and oragnobismuth polymers of biologically active monomers such as glycyrrhetinic acid (GAH 2 ) [123], thiodiglycolic acid (TGH 2 ) [124] and norfloxacin (NFH 2 ) [125] as potential anti-cancer agents, Figure 20. IR spectroscopy, 1 H-NMR and MALDI MS were employed to characterise the reported polymers.…”

“…It is an inhibitor of 15-hydroxyprostaglandin dehydrogenase and delta-13-prostaglandin which gives rise to increased levels of prostaglandins. It is also is a potent inducer of mitochondrial permeability transition and can therefore trigger the pro-apoptotic pathway [123]. The organometallic Bi polymer of GA, BiPh 3 /GA, is described as a mixture of bridging and non-bridging structures about the Bi though largely non-bridging and asymmetric.…”

“…The reported chain length is 2500. The organometallic Bi polymer of GA, BiPh 3 /GA exhibited moderate activity against a pancreatic cell line (PANC-1, EC 50 = 3800 ng/mL) though cisplatin (AsPC-1, EC 50 = 1400 and PANC-1, EC 50 = 340 ng/mL) and the organometallic antimony polymer of GA, SbPh 3 /GA (AsPC-1, EC 50 = 1900 and PANC-1, EC 50 = 1700 ng/mL) exhibited superior activity against both pancreatic cell lines tested [123].…”