Synthesis of Optically Active Macrolides From L-Menthone Derivatives and Hydrazides of Adipic and 2,6-Pyridinedicarboxylic Acids

Yakovleva, M. P.; Denisova, K. S.; Mingaleeva, G. R.; Gazetdinov, R. R.; Ishmuratov, G. Yu.

doi:10.1007/s10600-018-2387-y

Cited by 4 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Макрогетероциклические соединения (Мс) проявляют нелинейно-оптические, люминесцентные, жидкокристаллические, противоопухолевые, антибактериальные свойства, которые позволяют широко использовать подобные молекулы в технике и медицине [1][2][3][4][5][6][7][8]. Все большее значение приобретают Мс с расширенной π-электронной системой и координационной полостью, которая способна вмещать один атом металла большого радиуса или несколько атомов меньшего радиуса.…”

Section: Introductionunclassified

Synthesis and Properties of Bisthiadiazoles with Ethyl and Butyl Spacers

Suvorova¹,

Petukhova²,

Данилова³

et al. 2020

Liq. Cryst. and their Appl.

View full text Add to dashboard Cite

This article is devoted to a selection of the most effective preparative method for the synthesis of bis(5-amino-1,3,4-thiadiazole-2-yl)alkanes. These compounds are binuclear diamines consisting of symmetrical 1,3,4-thiadiazole fragments connected by alkyl spacers of various lengths. The structures of the obtained compounds were determined by IR spectroscopy, mass-spectrometry and elemental analysis. The possibility of using these molecules as precursors for the synthesis of macroheterocyclic compounds with expended coordination cavity consisting of six small cycles was demonstrated. Optimal synthesis conditions of bis(5-amino-1,3,4-thiadiazole-2-yl)ethane and bis(5-amino-1,3,4-thiadiazole-2-yl)butane were found by variation of reaction time and temperature. Virtual screening of the obtained compounds was carried out in order to predict antibacterial and biological activities as well as toxic properties of the targeted products. On the basis of the known literature data on polynuclear diamines, the exhibition of the liquid crystal properties of the synthesized molecules is supposed.

show abstract