Nucleic acids U 0700Synthesis of Optically Active 1,4-Dioxane Nucleotide Analogues. -The relatively flexible 1,4-dioxane system in title compound (VIII) is used as equivalent to the sugar counterpart in natural nucleosides. The two ester groups will function as the vehicle for subsequent condensation into oligonucleotide analogues. A similarly prepared anomeric mixture of adenine analogues is not separable by chromatography. -(YU, Q.; KAFFARNIK, S.; CARLSEN*, P.; Synth. Commun. 38 (2008) 23, 4250-4264; Dep. Chem., Norw. Univ. Sci. Technol., N-7491 Trondheim, Norway; Eng.) -K. Woydowski 18-193