Synthesis of oligocaprolactone vinyl ether macromonomers and their use for indomethacin encapsulation in polymer nanoparticles based on polycaprolactone macromonomer–maleic anhydride–N‐vinyl pyrrolidone terpolymers

Abstract

International audienceOligocaprolactone macromonomers functionalized with vinyl ether have been synthesized by polymerization of ε-caprolactone in the presence of hydroxy ethyl or butyl vinyl ether and characterised by NMR and Maldi time-of-flight mass spectroscopy. These macromonomers have been copolymerized with maleic anhydride and N-vinyl pyrrolidone to give terpolymers, which have been used to obtain nanoparticles by the phase-separation-dialysis method. Previously dissolving indomethacin in the terpolymer solution allows one to encapsulate the drug inside the nanoparticles

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