Abstract:Lysine acetylation is a posttranslational protein modification mediating proteinprotein interactions by recruitment of bromodomains. Investigations of bromodomains have focused so far on the sequence context of the modification site and acylmodifications installed at lysine side chains. In contrast, there is only little information about the impact of the lysine residue that carries the modification on bromodomain binding. Here, we report a synthesis strategy for L-acetyl-homolysine from L-2-aminosuberic acid … Show more
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