Synthesis of Nucleosides

Abstract

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Access to Reverse Glycosyl Azides and Rare Sugar-Based Glycosyl Azides via Radical Decarboxylative Azidation: Divergent Synthesis of 4'-C-Azidonucleosides as Potential Antiviral Agents

“…Although numerous methods have been established for the synthesis of nucleosides, there are limited methods available to prepare 4'- C -azidonucleosides which are of paramount importance for drug discovery and development . Encouraged by efficient buildup of ribo -configured RGAs 6l – 6p , we envisioned that Vorbrüggen glycosylation, which involves coupling of properly protected 4- C -azidofuranosyl acetates and silylated nucleobases, would provide a novel and divergent approach to 4'- C -azidonucleosides and their analogues.…”