“…2-Substituted-4H-3,1-benzoxazin-4-one base has been utilized as potent inhibitors of human leukocyte elastase (Krantz et al, 1990) and serine proteases (Gutschow et al, 1998). The National Cancer Institute, Washington, USA has also shown interest in 1-[3-(7-chloro-4-oxo-3,1-benzoxazin-4-yl) phenyl] methyl pyridinium chloride (NSC-341, 964) (Johnson & Pattison, 1986), evaluating its anti-neoplastic activity. Initial studies on 2-substituted-4H-3,1-benzoxazin-4-one showed good cytotoxic activity (Pavlidis & Perry, 1994) and herbicidal properties (Hamprecht et al, 2004).…”