Synthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors

Antidepressants Modulate Behavioral, Biochemical, and Histological Alterations Induced by Chronic Aluminum Chloride Administration in Wistar Rats

“…In earlier studies, antidepressants such as citalopram, fluoxetine, paroxetine, sertraline, and several structural derivatives of escitalopram significantly inhibited cholinesterases. [34][35][36][37] Consistent with earlier studies, rivastigmine and escitalopram caused further decline in AChE enzyme levels, thereby protecting and sustaining the function of remaining ACh from cholinergic nerve endings and improving cognition which was evident from the results of MWM trials in the present study. Furthermore, duloxetine-treated rats showed a decline in cholinesterase and improved cognition.…”

Discovery of novel 1,2,4-triazole tethered β-hydroxy sulfides as bacterial tyrosinase inhibitors: synthesis and biophysical evaluation through in vitro and in silico approaches

“…Later, the organic layer was dried over Na 2 SO 4 (anhydrous) which was puried by column chromatography using n-hexane/ EtOAc. 38,39,44,45 3.1.3. Synthesis of ester from 2-bromo-4-chlorophenol.…”

“…The washed organic layer was then dried over Na 2 SO 4 (anhydrous) which was subjected to purication by column chromatography using n-hexane/EtOAc. 36,38,39,44,45 3.1.4. Synthesis of hydrazides 6a-h. Hydrazine monohydrate (6 mmol) was added dropwise to the solution of respective ester (1 mmol) in ethanol 0 °C and the reaction solution was stirred for 12-16 h/overnight.…”

Recent Advances Towards the Synthesis of Dihydrobenzofurans and Dihydroisobenzofurans

“…[67,68] Pharmaceuticals such as Citalopram (29), [69] and Talopram (30), [70] act as powerful selective serotonin reuptake and norepinephrine transporters inhibitors, respectively. [69,[71][72][73] Few 1,3-dihydroisobenzofuran derivatives can inhibit cholines-terase (31), [74] cancer cell proliferation (32), [75] and peptide deformylase. [76] Also, it acts as anti-microbial (33), [76,77] and antidepression agents (34).…”