Synthesis of novel thiazol‐5‐ylpyrimidine derivatives and their antimicrobial evaluation

Abstract

Novel thiazol‐5‐ylpyrimidine derivatives were designed and synthesized. The chemical structures of all new synthesized compounds were assigned by studying their elemental analyses and spectral data (FT‐IR, 1HNMR, 13C NMR, and MS). The target compounds, 8 and 9a‐9d were evaluated for their antimicrobial activity in vitro against gram‐positive bacteria, Bacillus subtilis and Staphylococcus aureus, gram‐negative bacteria, Salmonella abony and Escherichia coli and fungi, Aspergillus flavus and Fusarium oxysporum. In particular, compounds 9a‐9c exhibited moderate to good activity against gram‐positive bacteria, S. aureus, gram‐negative bacteria, S. abony and fungus, Fusarium oxysporum in comparison with reference drugs.

Copper-mediated [3 + 2] oxidative cyclization of oxime acetate and its utility in the formal synthesis of fentiazac

“…16 Thereafter, several conditions for the Suzuki coupling were studied over substrate 7 (Table 2). 17,18 None of them could furnish our expected product (Table 2, entries a–f). To our delight, the formation of the product was observed using Pd 2 dba 3 as a catalyst (Table 2, entry g).…”