Synthesis of Novel Substituted Isoquinolones.

Abstract

Synthesis of Novel Substituted Isoquinolones.-Curtius rearrangement of cinnamoyl azides derived from cinnamic acids is found to be a suitable method for the synthesis of many isoquinolones. For substrates bearing electron-withdrawing substituents at the phenyl ring, the route via rearrangement of isoquinoline N-oxides (VI) is more successful. -(BRIET, NICOLAS; BROOKES, MICHAEL H.; DAVENPORT, RICHARD J.; GALVIN, FRANCES C. A.; GILBERT, PHILIP J.; MACK, STEPHEN R.; SABIN, VERITY; Tetrahedron 58 (2002) 29, 5761-5766; Celltech R&S,