Synthesis of Novel Substituted Indazoles via Nucleophilic Substitution of Hydrogen (S_NH)

Antiproliferative and apoptotic activity of new indazole derivatives as potential anticancer agents

“…We successfully developed conditions to obtain crystals of one compound of each family. The X‐ray diffraction analysis of compounds 3d and 5b (Figure 2) [ 21 ] unambiguously confirmed that compound 3d was obtained through a nucleophilic substitution of the hydrogen (S N H) atom at position 4 of 7‐nitroindazole. It also confirmed the geometry of the oxime function in relation to the indazole ring, which remained the same after the reaction with the arylsulfonyl chlorides.…”

“…These convenient and efficient protocols were recently described by our group to generate diversified functionalized indazoles. [ 21 ]…”

“…These convenient and efficient protocols were recently described by our group to generate diversified functionalized indazoles. [21] All structures were confirmed by 1 H, 13 C nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. We successfully developed conditions to obtain crystals of one compound of each family.…”

“…[9][10][11][12][13][14][15][16] Our research team has previously synthesized several indazoles bearing a sulfonamide moiety with good antiproliferative activities. [17][18][19][20][21] In fact, some of these compounds exerted a pharmacologically inter-…”

“…Our research team has previously synthesized several indazoles bearing a sulfonamide moiety with good antiproliferative activities. [ 17–21 ] In fact, some of these compounds exerted a pharmacologically interesting antiproliferative/apoptotic activity against human (DU145, HCT116, HT29, A2780, and A549) and murine (L1210 and P388) cell lines. Compounds I and II were the most active of the series of indazoles (Figure 1).…”