Synthesis of Novel Structurally Diverse N‐Mono‐ and N,N′‐Disubstituted Benzimidazol‐2‐one Derivatives by the Alkylations of 1,3‐Dihydro‐2H‐benzimidazol‐2‐one with Some Alkyl Halides under Transfer Catalysis Conditions
Abstract:A series of N‐mono‐ and N,N′‐disubstituted benzimidazol‐2‐one derivatives optionally substituted on both secondary amine functionalities were prepared with excellent yields by reacting 1,3‐dihydro‐2H‐benzimidazol‐2‐one in one and two steps respectively with various alkyl halides under phase transfer catalytic conditions. One of the synthesized N,N‐disubstituted benzimidazol‐2‐one derivatives underwent a regiospecific 1,3‐dipolar cycloaddition reaction at its side allyl substituent with the in situ generated 4‐… Show more
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