Synthesis of novel pyrimidine derivatives with (pyridin-3-ylmethyl)thio and phenylamino moieties and evaluation of their antifungal activity

Wang, Shi-Chun; Gao, Jigang; Zhang, Shuai; Liu, Si; Jiang, Lin

doi:10.1080/10426507.2017.1395439

Cited by 13 publications

(13 citation statements)

References 19 publications

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“…121 Anti-bacterial activities of the 3-functionalized benzofuran products against plant pathogens. Both the benzofuran 2 and the heteroatom [122][123][124] fragments of the 3-substituted benzofuran products obtained from this radical reaction have exhibited proven anti-bacterial activities against various pathogens in living organisms. We have long been devoted into the search and development of novel small molecular structures for pesticide innovations and applications.…”

Section: Resultsmentioning

confidence: 99%

Facile Access to Benzofuran Derivatives through Radical Reactions with Heteroatom-centered Super-electron-donors

Robin

Jiang

Wang

et al. 2023

Preprint

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Heteroatom anions are applied as super-electron-donors (SEDs) to initiate radical reactions for facile synthesis of 3-substituted benzofurans. Phosphines, thiols and anilines bearing different substitution patterns work well in this inter-molecular radical coupling reaction and the 3-functionalized benzofuran products bearing heteroatomic functionalities are given in moderate to excellent yields. The reaction mechanism is elucidated via control experiments and computational methods. The afforded products showed promising applications in both organic synthesis and pesticide development.

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Section: Resultsmentioning

confidence: 99%

Facile Access to Benzofuran Derivatives through Radical Reactions with Heteroatom-centered Super-electron-donors

Robin

Jiang

Wang

et al. 2023

Preprint

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“…Wang et al [89] have synthesized pyrimidine derivatives (38 a-h) with a (pyridin-3-ylmethyl)thio and a phenylamino moiety and evaluated the antifungal activity against B. cinerea and S. sclerotiorum (Figure 30). The biological data indicated that all target compounds (38 a-h, inhibition rates: 66.4 %-79.9 %) displayed moderate antifungal activity against B. cinerea at 50 μg/mL.…”

Section: Pyrimidines (Plant Antifungal Agents)mentioning

confidence: 99%

“…Wang et al [89] . have synthesized pyrimidine derivatives ( 38 a – h ) with a (pyridin‐3‐ylmethyl)thio and a phenylamino moiety and evaluated the antifungal activity against B. cinerea and S. sclerotiorum (Figure 30).…”

Section: Monocyclic Compoundsmentioning

confidence: 99%

SAR Analysis of Heterocyclic Compounds with Monocyclic and Bicyclic Structures as Antifungal Agents

Liu

Sun

et al. 2022

ChemMedChem

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Infections caused by eukaryotic organisms, such as fungi, are generally more difficult to treat than bacterial infections. With the widespread use of antifungal drugs in humans and plants, resistance and toxicity have emerged. Therefore, it is desirable to develop new antifungal drugs with low toxicity that are not susceptible to the development of resistance. This review presents a summary of the past few years (2017-2021) of research on heterocyclic compounds as antifungal agents for use in humans and plants, focusing on the structure-activity relationships (SAR) of these compounds. This review may provide ideas and information for designing and developing new antifungal drugs with fewer side effects compared with currently available drugs.

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“…In 2018, Wang and coworkers [47] synthesized a series of novel thioether derivatives containing a pyrimidine moiety and evaluated for their in vitro fungicidal activities against B. cinerea and S. sclerotiorum. Antifungal activity of compound 36 (Figure 8) revealed the best inhibitory activity (93.7%) against S. sclerotiorum at 100 μg/mL, which was superior to those of Triadimefon and Chlorothalonil.…”

Section: Antifungal Activitymentioning

confidence: 99%

Recent achievements on the agricultural applications of thioether derivatives: A 2010–2020 decade in review

Yang²,

Wang

et al. 2021

Journal of Heterocyclic Chem

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Thioether derivatives, an important synthetic strategy in drug discovery, are acquiring more importance in plant protection field in recent years because of their broad spectrum of agricultural activities, such as antifungal, antibacterial, insecticidal, acaricidal, nematocidal, antiviral, herbicidal, and plant growthregulating activity. Thioethers and their analogues have been an area of great interest in recent years. This review summarizes the structure and agricultural activities of the thioether derivatives as reported in the literature that mainly covers the past 10 years from 2010 to 2020 as well as may contribute to a better understanding of thioether derivatives as efficient agricultural agents and provide some ideas on the development of novel pesticides.

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Synthesis of novel pyrimidine derivatives with (pyridin-3-ylmethyl)thio and phenylamino moieties and evaluation of their antifungal activity

Cited by 13 publications

References 19 publications

Facile Access to Benzofuran Derivatives through Radical Reactions with Heteroatom-centered Super-electron-donors

Facile Access to Benzofuran Derivatives through Radical Reactions with Heteroatom-centered Super-electron-donors

SAR Analysis of Heterocyclic Compounds with Monocyclic and Bicyclic Structures as Antifungal Agents

Recent achievements on the agricultural applications of thioether derivatives: A 2010–2020 decade in review

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