Synthesis of novel poly (vinyl alcohol)/tamarind gum/bentonite-based composite films for drug delivery applications

Qureshi, Dilshad; Behera, Kiran Prava; Mohanty, Debashish; Mahapatra, S. K.; Verma, Sarika; Sukyai, Prakit; Banerjee, Indranil; Pal, Sumit; Mohanty, Biswaranjan; Kim, Doman; Pal, Kunal

doi:10.1016/j.colsurfa.2020.126043

Cited by 36 publications

(18 citation statements)

References 82 publications

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“…In [ 53 ], a reduction in UV region transparency of HPMC/pectin films was observed with the upsurge in pectin (a polysaccharide) content. Furthermore, increased TG content reduced the film’s transparency due to the increased TG density within the films, which corresponds with previously cited studies of Yadav et al [ 44 ] and Qureshi et al [ 45 ]. This was explained by decreased interchain polymer spacing as the TG content is increased [ 54 ].…”

Section: Resultssupporting

confidence: 90%

“…The FTIR study confirms the decrease in hydrogen bonding from F0 to F2 [46]. The swelling behavior of the films followed the same order as predicted from the In their work, Yadav et al [44] used nanotubes and graphene oxide to fill PVA and carboxymethyl tamarind gum and found that the resulting films were homogeneous. Their microscopic SEM observations indicated the presence of globular structures placed within an uninterrupted polymer matrix were present.…”

Section: Swelling Studysupporting

confidence: 71%

“…In their work, Yadav et al [ 44 ] used nanotubes and graphene oxide to fill PVA and carboxymethyl tamarind gum and found that the resulting films were homogeneous. Their microscopic SEM observations indicated the presence of globular structures placed within an uninterrupted polymer matrix were present.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

Rawooth

Habibullah²,

Qureshi

et al. 2022

Polymers

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The current study aims to evaluate the effect of tamarind gum (TG) on the optical, mechanical, and drug release potential of poly(vinyl alcohol) (PVA)-based films. This involves preparing PVA-TG composite films with different concentrations of TG through a simple solvent casting method. The addition of TG has enhanced the phase separation and aggregation of PVA within the films, and it becomes greater with the increase in TG concentration. Brightfield and polarized light micrographs have revealed that aggregation is favored by forming crystalline domains at the PVA-TG interface. The interconnected network of PVA-TG aggregates influenced the swelling and drying properties of the films. Using Peleg’s analysis, the mechanical behavior of films was determined by their stress relaxation profiles. The addition of TG has made no significant changes to the firmness and viscoelastic properties of films. However, long-durational relaxation times indicated that the interconnected network might break down in films with higher TG concentration, suggesting their brittleness. The controlled release of ciprofloxacin in HCl solution (0.5% (w/v)) appears to decrease with the increase in TG concentration. In fact, TG has inversely affected the impedance and altered the ionic conductivity within the films. This seems to have directly influenced the drug release from the films as the mechanism was found to be non-Fickian diffusion (based on Korsmeyer–Peepas and Peppas–Sahlin kinetic models). The antimicrobial study using Escherichia coli was carried out to evaluate the activity of the drug-loaded films. The study proves that TG can modulate the properties of PVA films and has the potential to fine-tune the controlled release of drugs from composite films.

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Section: Resultssupporting

confidence: 90%

Section: Swelling Studysupporting

confidence: 71%

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Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

Rawooth

Habibullah²,

Qureshi

et al. 2022

Polymers

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“…Though polysaccharides often are insoluble in common solvents that limits processing, some dissolution media like ionic solvents may dissolve polysaccharides [80]. Polysaccharidenanoclay based nano-composites bestow diverse applications, like drug release in cancer therapy [81], biodegradable antimicrobial active food packaging films [82,83], drug delivery [84] and insulating building materials [62]. They are also applied to remove harmful microbes, inorganic and organic pollutants from wastewater [85].…”

Section: Fig 4 Applications Of Nanoclay-polysaccharide Nanocompositesmentioning

confidence: 99%

Nontronite-Starch based Nano-Composites and Applications

Bajpai¹

2022

Materials Research Foundations

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Polymer nano-composites consist of two or more constituents with at least one being of nanoscale dimension. Being naturally abundant, affordable, non-toxic and biocompatible, clay-based minerals and biopolymers are advantageous to afford eco-friendly nanocomposites, especially useful for biological applications. Starch, a common polysaccharide, finds traditional use in the food industry, and has recently become relevant in several advanced technologies. Nontronite, an iron rich smectite clay, still remains underexplored in the context of nanocomposite preparation. This book chapter attempts to provide a brief overview of syntheses and applications of nanocomposites based on nontronite, starch and polysaccharide-clay.

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“…These materials exhibit a very remarkably enhanced mechanical and barrier properties combined with a good thermal and chemical stability [5][6][7][8]. Bentonite clays are largely used in many industrial products such as ceramics, paintings, coatings, drilling mud, etc...…”

Section: Introductionmentioning

confidence: 99%

Plasticizing Properties Improvement of Poly (4-Vinylpyridine)/Clay Composites: Effect of Composition and Clay Nature

Dergal

Lerari

Bachari

2021

Advances in Materials Science

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A significant number of investigations have been reported on the elaboration and characterization of Polymer/Clays composites, via different methods. In our work, new composites materials were successfully prepared by in-situ polymerization of 4-vinylpyridine (4VP), in presence of two different types of Algerian modified clays (Maghnia and Mostaganem), noted (BC) and (MC), respectively. Different percentage clays (1 wt%, 3 wt% and 5 wt%) have been used. The differential scanning calorimetry analysis reveals the variation of glass transition temperature (Tg) of the copolymer in the composite materials. We show a decrease glass transition temperature (Tg) from 147°C to 131°C for P4VP-BC and from 147°C to 124°C for P4VP-MC according to the increase percentage of clays. Thermogravimetric analysis (TGA) shows good stability of composite materials at high temperature. Fourier Transformed Infrared (FTIR), Scanning Electron Microscopy coupled with Energy dispersive X-Ray Spectroscopy (SEM-EDX) and 1H NMR spectroscopy are used to show the presence of the clays in the materials.

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Synthesis of novel poly (vinyl alcohol)/tamarind gum/bentonite-based composite films for drug delivery applications

Cited by 36 publications

References 82 publications

Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

Nontronite-Starch based Nano-Composites and Applications

Plasticizing Properties Improvement of Poly (4-Vinylpyridine)/Clay Composites: Effect of Composition and Clay Nature

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