Synthesis of novel metal (II) complexes tailored from 9-oxo-9H-fluorene-1-carboxylic acid via green protocol: DNA cleavage and anticancer studies

Kumbar, Mahantesh; Patil, Sangamesh A.; Toragalmath, Shivakumar S.; Jawoor, Shailaja S.; Shettar, Arun Kashivishwanath

doi:10.1016/j.ica.2019.119210

Cited by 16 publications

(3 citation statements)

References 40 publications

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“…The essential precursors, the ligands, and their associated metal complexes (Figure 19) were reported by Kumbar et al 100 in the current work along with two novel ligands. A comparison of metal complexes and their associated ligand L31 in treated cells versus untreated control cells (NC) has been made using fluorescence microscopy.…”

Section: Dna Interactionsupporting

confidence: 63%

“…The essential precursors, the ligands, and their associated metal complexes (Figure 19) were reported by Kumbar et al 100 untreated control cells (NC) has been made using fluorescence microscopy. The metal complexes have been characterized by elemental analysis, thermal and molar conductivity and spectral (1H, 13C nuclear magnetic resonance, IR, GC-MS, electronic) measurements.…”

Section: Intercalationmentioning

confidence: 99%

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Recent advances on the DNA interaction properties of Schiff bases and their metal complexes

Yadav,

Poonia

2024

Applied Organom Chemis

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Cancer has become the second leading reason for death in the world. Cell biology states that the bulk of anti‐cancer medications focuses on DNA. A study of how complexes of metals interact with DNA is crucial in creation of the effective chemotherapy drugs. The interactions of DNA with Schiff base and their metal complexes are a thrust area for many researchers, and many papers have reported on them. An amino molecule reacts with carbonyl group to form a variety of chemicals called Schiff bases. Many studies have shown that Schiff bases have compounds that affect biological processes. Due to their potential use as novel reagents for biotechnology and medicine, the research of interactions between transition metal complexes and nucleic acids has grown significantly during the past few decades. It was shown that several metal Schiff base complexes may intercalate DNA. Small molecules can attach themselves to DNA through different ways, such as intercalation and groove binding. The main method to measure nuclease activity was gel electrophoresis, and the ligand alone had much lower activity than the complex. To set the stage for this analysis, a brief overview of Schiff bases and their complexes is provided. Further, this review provides an overview of the DNA interactions brought forth by Schiff base metal complexes. It also draws attention to new developments in the study of Schiff bases and their metal complexes and their prospective use as a bioactive core for DNA cleavage and binding.

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Section: Dna Interactionsupporting

confidence: 63%

Section: Intercalationmentioning

confidence: 99%

Recent advances on the DNA interaction properties of Schiff bases and their metal complexes

Yadav,

Poonia

2024

Applied Organom Chemis

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“…Azabenzo[a]fluorene-5,6-diones have comparable cytotoxicities against cancer cell lines in vitro, with that of standard drug doxorubicin [16]. Our previous publication [17] have successfully established the anticancer efficacy of copper complex of fluorenone based ligand; which exhibited better anticancer activity against human breast carcinoma (MCF-7) cell line when compared to that of standard drug paclitaxel.…”

Section: Introductionmentioning

confidence: 99%

Anticancer activity studies of novel metal complexes of ligands derived from polycyclic aromatic compound via greener route

Kumbar

Patil

Toragalmath³

et al. 2020

Journal of Organometallic Chemistry

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Fluorene Based Ferric Complex as Colorimetric and Fluorometric Probe for Highly Selective Detection of CN− and S2− Anions

Saltan

Dinçalp

2021

J Fluoresc

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Synthesis of novel metal (II) complexes tailored from 9-oxo-9H-fluorene-1-carboxylic acid via green protocol: DNA cleavage and anticancer studies

Cited by 16 publications

References 40 publications

Recent advances on the DNA interaction properties of Schiff bases and their metal complexes

Recent advances on the DNA interaction properties of Schiff bases and their metal complexes

Anticancer activity studies of novel metal complexes of ligands derived from polycyclic aromatic compound via greener route

Fluorene Based Ferric Complex as Colorimetric and Fluorometric Probe for Highly Selective Detection of CN− and S2− Anions

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