Synthesis of Novel Mannich Bases on the Base of 1-Phenoxy-3-Propylthiopropane-2-Ol and Secondary Amines

Abstract

The condensation of 1-phenoxy-3-propylthiopropan-2-ol with formaldehyde and secondary aliphatic, as well as heterocyclic amines, has led to the formation of new aminomethoxy derivatives of 1-phenoxy-3propylthiopropane with 69-77% yields. The physico-chemical parameters of the synthesized compounds were determined, their structure was confirmed by the methods of elemental analysis, IR spectroscopy, 1 H and 13 С NMR. The compounds obtained were tested as antiseptic substances against bacteria and fungi. It is established that they are more effective than the currently used medical drugs.