Synthesis of Novel Magnetic Quercetin-Neuropeptide Nanocomposite as a Smart Nano-Drug Shuttle System: Investigation of Its Effect on Behavior, Histopathological Characteristics, and Expression of MAPT and APP Genes in Alzheimer’s Disease Rats
Kamelia Mobasheri,
Mohammad Zaefizadeh,
Maryam Ghobeh
et al.
Abstract:Background: Alzheimer’s disease (AD) is the most common type of dementia. The drugs introduced for this disease have many side effects and limitations in use, so the production of a suitable herbal medicine to cure AD patients is essential. Objective: The aim of this research is to make a magnetic neuropeptide nano shuttle as a targeted carrier for the transfer of quercetin to the brains of AD model rats. Methods: In this work, a magnetic quercetin-neuropeptide nanocomposite (MQNPN) was fabricated and administ… Show more
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