Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention

Abstract

In this contribution, we report synthetic strategies towards potential ligands for the study of binding differences between PhzE, the first enzyme in the biosynthesis of phenazines, and the related enzyme anthranilate synthase. The ligands were designed with the overriding goal to develop new antibiotics via downregulation of phenazine biosynthesis.Graphical abstract Electronic supplementary materialThe online version of this article (10.1007/s00706-017-2100-z) contains supplementary material, which is available to authorized users.

Colour Me Blue: The History and the Biotechnological Potential of Pyocyanin

“…Phenazine-producing organisms exhibit an increase in life-span in any environment in which they develop. This is extremely relevant for maintenance in the environment [ 57 ]. P. aeruginosa can grow in oligotrophic environments and produces less pyocyanin when exposed to water, compared to enriched media or soil [ 58 ].…”