2021
DOI: 10.1016/j.bmc.2021.116453
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Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential

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Cited by 26 publications
(16 citation statements)
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“…Statistical evaluation was performed using a two-way ANOVA analysis followed by Tukey’s multiple comparisons test. Data were considered statistically significant if ** p < 0.01, *** p < 0.001, **** p < 0.0001 [ 63 ].…”
Section: Methodsmentioning
confidence: 99%
“…Statistical evaluation was performed using a two-way ANOVA analysis followed by Tukey’s multiple comparisons test. Data were considered statistically significant if ** p < 0.01, *** p < 0.001, **** p < 0.0001 [ 63 ].…”
Section: Methodsmentioning
confidence: 99%
“…A series of novel indole-azolidinone hybrids with 5-fluoro-3-formyl-1 H -indole-2-carboxylic acid methyl ester scaffolds were synthesized via the Knoevenagel reaction [ 55 ]. Among the synthesized compounds, hybrid 57 ( Figure 22 ) was found to be the most active and exhibited toxicity in the 60 lines screening, with total GI 50 of 0.45/0.65 µM and with IC 50 values toward cancer cells MCF-7-0.70 µM, HCT116-0.80 µM, A549-9.70 µM, and HepG2-12.00 µM.…”
Section: Privileged Heterocyclic Scaffolds–4-thiazolidinones Hybrid M...mentioning
confidence: 99%
“…Among the synthesized analogues, indole‐rhodanine hybrid 141 demonstrated excellent anticancer activity with a GI 20 value of <0.01 μM against the HepG2 cell line. The incorporation of rhodanine at the C‐3 position of indole showed excellent cytotoxicity against the HepG2 cell line [35] …”
Section: Pharmacological Significance and Sarmentioning
confidence: 99%