Synthesis of novel fused thienodiazaphosphorine derivatives from 2-amino-3-cyanothiophenes and Lawesson's reagent

The Dimroth Rearrangement in the Synthesis of Condensed Pyrimidines – Structural Analogs of Antiviral Compounds

“…An analysis of the literature over the past 10 years has identified several studies that were not included in the 2017 review on the Dimroth rearrangement. 30 In addition, in the last three years, a number of new publications have been published on the synthesis of a wide variety of heterocyclic systems, namely, 2-aminoimidazolotriazoles (2-substituted triazoles), 31 [1,2,4]triazolo [1,5-a]pyridines, 32 7,8,9,10-tetrahydro [1,2,4] 36 and thieno- [2,3- 37 relying the Dimroth rearrangement, indicating its enormous potential.…”

Reaction of Lawesson's reagent with Mannich base hydrochlorides: synthesis of novel 4H-1,3,2-oxathiaphosphorine-2-sulfide derivatives

“…With this in mind, and in continuation of our research on the use of LR for the synthesis of novel heterocyclic scaffolds with possible biological properties, [20][21][22][23] we have investigated the reaction of LR with Mannich base hydrochlorides derived from acyclic and cyclic ketones, which could represent an easy and general method to access novel types of 4H-1,3,2-oxathiaphosphorine derivatives.…”

The First Synthesis of [1,2]oxaphosphinino[6,5-c]pyrazoles by Thiophosphorylation of 6-Aminopyrano[2,3-c]pyrazole-5-Carbonitriles

“…Meanwhile, the presence of an enaminonitrile fragment in molecule 1 makes this class of compounds a promising substrate for further transformations. Thiophosphorylation of enaminonitriles (ortho-aminocarbonitriles) using P4S10 or Lawesson reagent (LR, 2,4-bis(4-methoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane) was reported to afford 1,3,2λ 5 -diazaphosphinanes [5][6][7][8][9][10][11]. For 2-amino-3-cyano-4H-pyran and chromenes, such reactions have been described in only a few recent papers.…”