Synthesis of novel fused 4,5-dihydro-1,2,3-triazolo[1,5-a][1,4]benzodiazepine derivatives via four-component Ugi–Smiles-type reaction

CuBr/Et3N‐Promoted Reactions of 2‐Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin‐4(3H)‐ones

“…The sequence for the proposed reaction initiated by treating isatoic anhydride ( 1 ) with various amines 2 in H 2 O at room temperature affording the related 2‐aminobenzamides 3 . All compounds 3 were easily prepared and used without further purifications.…”

“…The general approach has been depicted in Scheme . In connection with our interest in the synthesis of N ‐heterocycles , particularly using isatoic anhydride as a starting material, herein, we disclose a CuBr/Et 3 N promoted synthesis of 3‐substituted 2‐(arylamino)quinazolin‐4(3 H )‐ones 5 via the reaction of 2‐aminobenzamides 3 obtained from 1 and various amines 2 , with aryl isothiocyanates 4 ( Scheme ).…”

Synthesis of New Benzimidazole‐1,2,3‐triazole Hybrids as Tyrosinase Inhibitors

“…Moreover, 1,2,3‐triazloles have been introduced as the peptide bond isosteres and 1,2‐3‐triazole‐containing analogs of the naturally occurring cyclo[Pro‐Val‐Pro‐Tyr] have shown potent tyrosinase inhibitory activity . 1,2,3‐Triazole moiety is not naturally produced; hence, synthetic molecules have attracted lots of attention and in this regard, copper(I)‐catalyzed formation of 1,2,3‐triazoles through the reaction of azides and terminal alkynes has been a powerful tool in drug discovery developments …”

Synthesis of novel fused quinazolinone derivatives

“…Furthermore, some isoindoloquinazolinediones were synthe- [17,20,21]. Focusing on the biological potential of fused quinazolinones, in continuation of our work on the synthesis of novel N -heterocycles [22][23][24][25][26][27][28], herein, we report the synthesis of novel fused quinazolinones 8 and 10 starting from isatoic anhydride 1 (Scheme 1).…”