Synthesis of Novel Fluorinated Bisphosphonates and Bisphosphonic Acids

Experimental and theoretical studies on the transannular cyclizations of 3,7-dimethylenebicyclo[3.3.1]nonane with polyfluoroalkyl radicals

“…Ethyl iododifluoroacetate [25] and diethyl iododifluoromethylphosphonate [38,39] were prepared by literature procedures. Copper powder was activated before use [40].…”

Synthesis of γ-butyrolactones containing α,α-difluoromethylenyl bisphosphonate initiated by Na2S2O4

“…3 was obtained in excellent yield from triethyl phosphite (2) according to literature [12] (Scheme 1).…”

The development of bisphosphonates for therapeutic uses, and bisphosphonate structure-activity consideration

“…However, this route gave lower yields, and the product-isolation is more difficult owing to increased formation of side products. 38,39 Furthermore, a novel type of fluorinated bisphosphonates could be prepared. When the trifluoro-acetimidoyl chlorides 11a,b were allowed to react with diethyl phosphonate (2b), the α-(sulfonylamino)trifluoroethylidene-bisphosphonates (14a,b) were formed as outlined in …”