Synthesis of novel coumarin derivatives bearing dithiocarbamate moiety: An approach to microwave, molecular docking, Hirshfeld surface analysis, DFT studies and potent anti-microbial agents

Mangasuli, Sumitra N.; Hosamani, Kallappa M.; Managutti, Praveen B.

doi:10.1016/j.molstruc.2018.12.049

Cited by 22 publications

(6 citation statements)

References 30 publications

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“…Coumarin bearing dithiocarbamate derivatives were synthesized and evaluated by their in vitro antimicrobial potential against both Gram-positive, Gram-negative bacterial strains by S.N. Mangasuli et al [34]. The study includes evaluation against bacterial strains, namely, S. aureus, B. subtilis, E. coli, and P. aeruginosa, and fungal strains, namely, A. flavus, Trichoderma harzianum, and Penicillium chrysogenum, and yeast C. albicans using the macrodilution broth method.…”

Section: Antimicrobial Spectrum Of Coumarinsmentioning

confidence: 99%

Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery

Cheke¹,

Patel

Patil³

et al. 2022

Antibiotics

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A major global health risk has been witnessed with the development of drug-resistant bacteria and multidrug-resistant pathogens linked to significant mortality. Coumarins are heterocyclic compounds belonging to the benzophenone class enriched in different plants. Coumarins and their derivatives have a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumour, and enzyme inhibitory effects. In the past few years, attempts have been reported towards the optimization, synthesis, and evaluation of novel coumarin analogues as antimicrobial agents. Several coumarin-based antibiotic hybrids have been developed, and the majority of them were reported to exhibit potential antibacterial effects. In the present work, studies reported from 2016 to 2020 about antimicrobial coumarin analogues are the focus. The diverse biological spectrum of coumarins can be attributed to their free radical scavenging abilities. In addition to various synthetic strategies developed, some of the structural features include a heterocyclic ring with electron-withdrawing/donating groups conjugated with the coumarin nucleus. The suggested structure−activity relationship (SAR) can provide insight into how coumarin hybrids can be rationally improved against multidrug-resistant bacteria. The present work demonstrates molecular insights for coumarin derivatives having antimicrobial properties from the recent past. The detailed SAR outcomes will benefit towards leading optimization during the discovery and development of novel antimicrobial therapeutics.

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Section: Antimicrobial Spectrum Of Coumarinsmentioning

confidence: 99%

Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery

Cheke¹,

Patel

Patil³

et al. 2022

Antibiotics

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“…Antimicrobial research was extended to coumarin–carbonodithioate derivatives by the same research group. [ 49 ] Here, they focused on C‐4‐substituted coumarin derivatives with modification at the carbonodithioate functionality, wherein various secondary amines are attached to form dithiocarbamates. Interestingly, dithiocarbamate derivatives with a butyl chain showed excellent antibacterial and antifungal activities.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Pharmacological report of recently designed multifunctional coumarin and coumarin–heterocycle derivatives

Dorababu

2021

Archiv der Pharmazie

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Coumarin is a naturally available molecule and has been identified as a potent pharmacophore due to its pharmacological activity. Because of this, coumarin has been exploited synthetically to prepare a wide range of derivatives. In fact, most coumarin derivatives have been found to be less toxic, which is the most essential property for a drug molecule. Such molecules are being prepared for therapeutic use as broad‐spectrum pharmacological agents. Microbial diseases including viral diseases have become very common and are responsible for many deaths worldwide. In particular, microbial drug resistance is a problem that needs to be tackled in an effective manner. Also, for Alzheimer's disease, which affects most elderly persons, no efficient chemotherapy exists. In addition, although diabetes, a metabolic syndrome, can be treated with many drugs, there is no complete cure. Thus, more potent antidiabetic agents are required for the management of diabetes. Likewise, for the treatment of a wide range of ailments caused by microbes, genetic factors, or lifestyle‐related factors, an efficient drug regimen is needed. In view of this, coumarin derivatives are designed and evaluated. Here, coumarin derivatives that have been reported recently are compiled, classified and evaluated critically. This study briefly takes the structure–activity relationship into consideration and suggests the next suitable step. With a focus on the most potent molecules, the pharmacological activity of the evaluated molecules is described.

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“…183,184 These methodologies laid the foundation for the development of processes that obtain coumarin compounds. 171 These new methodologies are based on the use of different reactions and catalytic processes in which the precursors and materials used to obtain coumarins vary, involving ecological approaches, new technologies, such as microwaves 184 and ultrasound, 185 new catalysts, 186,187 ecological solvents, 188 reactions without Solvents 189 and molecular coupling, 190,191 among others, resulting in coumarins with greater yields and better activity, demonstrating the importance of coumarin compounds in different industries and providing coumarin derivatives in recent years that are much more easily obtained, economical and environmentally responsible.…”

Section: Synthesis Of Coumarinsmentioning

confidence: 99%

Background on the control of the cattle tick R. (B.) microplus and the use of coumarin substances as an alternative

Molano¹,

Torres²,

Monrroy³

2020

PPIJ

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Synthesis of novel coumarin derivatives bearing dithiocarbamate moiety: An approach to microwave, molecular docking, Hirshfeld surface analysis, DFT studies and potent anti-microbial agents

Cited by 22 publications

References 30 publications

Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery

Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery

Pharmacological report of recently designed multifunctional coumarin and coumarin–heterocycle derivatives

Background on the control of the cattle tick R. (B.) microplus and the use of coumarin substances as an alternative

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