Synthesis of Novel Chromenes as Cytotoxic Agents

Abstract

Novel substituted chromenes, chromenopyrimidines and chromenotriazolopyrimidines were synthesised to explore their anticancer activity. Several compounds were evaluated for their antitumour activity, most of them revealed promising cytotoxic activity against breast cancer cell line MCF-7 in comparison to colchicine as positive control.Scheme 1 Synthesis of compounds 2a and 2b, 3a and 3b, and 4a and 4b.Scheme 2 Synthesis of compounds 5a and 5b, 6a-d and 7a and 7b.

Recent advances on the synthesis of azoles, azines and azepines fused to benzimidazole

“…188 However, condensation of the arylhydrazones 326 with 2-benzimidazoleacetonitrile 59 in refluxing acetic acid gave the 3-methyl-2-arylazopyrido[1,2-a]benzimidazoles 327 (Scheme 111). …”