Synthesis of novel chitosan-PVC conjugates encompassing Ag nanoparticles as antibacterial polymers for biomedical applications

Gaballah, Samir T.; Nazer, Hossam A. El; Abdel-Monem, Reham A.; El‐Liethy, Mohamed Azab; Hemdan, Bahaa A.; Rabie, Samira T.

doi:10.1016/j.ijbiomac.2018.10.085

Cited by 67 publications

(28 citation statements)

References 48 publications

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“…The results obtained demonstrate that the metal NPs were extremely bactericidal against the experimental bacterial species. Similar results had recently been published (Gaballah et al 2019). Similarly, Usman et al (2013) tested the antimicrobial effect of chitosan NPs with Cu on different bacterial and fungal species and concluded that the tested NPs could effectively inactivate the infectious microbes investigated.…”

Section: Antibacterial Assay and Micsupporting

confidence: 79%

Nanoceramics and novel functionalized silicate-based magnetic nanocomposites as substitutional disinfectants for water and wastewater purification

Nahwary

Hemdan

Abia

2020

Environ Sci Pollut Res

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Herein, we successfully synthesized nano-porous Co 2 O 3 /Cu 2 O 3 : Al 2 O 3 : SiO 2 ((0, 5, 7, 9) Co-CAS) using the acidic sol-gel approach and calcined at 800°C for 4 h. The crystallization behavior and spectroscopic properties were investigated using X-ray diffraction, field emission-scanning electron microscopy, and Fourier-transform infrared absorption spectra analysis. The antibiotic properties of the nano-porous CAS, 5Co-CAS, and 9Co-CAS magnetic nanocomposites was studied against some potentially pathogenic bacteria in water and wastewater samples. The bacteria tested included Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa, Listeria monocytogenes, Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis. Incorporating Co 2 O 3 resulted in the identification of three peaks at 2θ = 10.2°, 13.4°, and 15°. The introduction of cobalt nanoparticles created a ferromagnetic behavior in the CAS nanoceramic, with the magnetic moment and saturation values increasing with increased Co 2 O 3 doping. 9Co-CAS was most potent against all the tested pathogens with minimum inhibitory concentrations of 25 mg/L within 40 min for E. coli and P. aeruginosa and 50 mg/L within 10 min for S. enterica; the lowest antibacterial activity was observed with the unmodified CAS. The findings revealed that the manufactured nanocomposite materials were potent disinfectants with a promising application for water and wastewater treatment.

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Section: Antibacterial Assay and Micsupporting

confidence: 79%

Nanoceramics and novel functionalized silicate-based magnetic nanocomposites as substitutional disinfectants for water and wastewater purification

Nahwary

Hemdan

Abia

2020

Environ Sci Pollut Res

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“…The use of spacer arms can enhance the binding of ligands to polysaccharides and provide a variety of binding sites. To date, functionalized chitosan with new reactive groups such as aldehyde groups, carbonyl groups, carboxyl groups, and thiol groups have been used widely for conjugations [82,97].…”

Section: Functional Group Conversion Strategymentioning

confidence: 99%

Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

Qin

2020

IJMS

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As a natural polysaccharide, chitosan possesses good biocompatibility, biodegradability and biosafety. Its hydroxyl and amino groups make it an ideal carrier material in the construction of polymer-drug conjugates. In recent years, various synthetic strategies have been used to couple chitosan with active substances to obtain conjugates with diverse structures and unique functions. In particular, chitosan conjugates with antimicrobial activity have shown great application prospects in the fields of medicine, food, and agriculture in recent years. Hence, we will place substantial emphasis on the synthetic approaches for preparing chitosan conjugates and their antimicrobial applications, which are not well summarized. Meanwhile, the challenges, limitations, and prospects of antimicrobial chitosan conjugates are described and discussed.

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“…DLS provides a hydrodynamic size and is more quantitative, while AFM and TEM offer both qualitative and quantitative information such as particle shape, surface morphology, and size of the NPs. Similarly, structural changes in the formation of ChNPs were reportedly observed employing TEM, AFM, SEM, Fourier-transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRD) [72,73,74,75,76].…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles

Rizeq

Younes

Rasool

et al. 2019

IJMS

209

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The development of advanced nanomaterials and technologies is essential in biomedical engineering to improve the quality of life. Chitosan-based nanomaterials are on the forefront and attract wide interest due to their versatile physicochemical characteristics such as biodegradability, biocompatibility, and non-toxicity, which play a promising role in biological applications. Chitosan and its derivatives are employed in several applications including pharmaceuticals and biomedical engineering. This article presents a comprehensive overview of recent advances in chitosan derivatives and nanoparticle synthesis, as well as emerging applications in medicine, tissue engineering, drug delivery, gene therapy, and cancer therapy. In addition to the applications, we critically review the main concerns and mitigation strategies related to chitosan bactericidal properties, toxicity/safety using tissue cultures and animal models, and also their potential environmental impact. At the end of this review, we also provide some of future directions and conclusions that are important for expanding the field of biomedical applications of the chitosan nanoparticles.

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Synthesis of novel chitosan-PVC conjugates encompassing Ag nanoparticles as antibacterial polymers for biomedical applications

Cited by 67 publications

References 48 publications

Nanoceramics and novel functionalized silicate-based magnetic nanocomposites as substitutional disinfectants for water and wastewater purification

Nanoceramics and novel functionalized silicate-based magnetic nanocomposites as substitutional disinfectants for water and wastewater purification

Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles

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