Synthesis of novel benzodioxane midst piperazine moiety decorated chitosan silver nanoparticle against biohazard pathogens and as potential anti-inflammatory candidate: A molecular docking studies

Karthik, C.S.; Manukumar, H.M.; Ananda, A.P.; Nagashree, S.; Rakesh, K.P.; Mallesha, L.; Qin, Hua‐Li; Umesha, S.; Mallu, P.; Krishnamurthy, N. B.

doi:10.1016/j.ijbiomac.2017.12.045

Cited by 48 publications

(21 citation statements)

References 54 publications

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“…Since the specific and selective delivery and action of therapeutic agents became one of the most studied topics for improving current human healthcare practice, nanoparticles received tremendous attention regarding the design and development of novel and enhanced drug-delivery systems [ 78 ]. In particular, AgNP-based nanosystems were evaluated as suitable carriers of various therapeutic molecules, including anti-inflammatory [ 79 , 80 ], anti-oxidant [ 81 , 82 ], antimicrobial [ 83 , 84 ], and anticancer [ 32 , 85 ] biosubstances.…”

Section: Silver Nanoparticles For Drug-delivery Systemsmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

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During the past few years, silver nanoparticles (AgNPs) became one of the most investigated and explored nanotechnology-derived nanostructures, given the fact that nanosilver-based materials proved to have interesting, challenging, and promising characteristics suitable for various biomedical applications. Among modern biomedical potential of AgNPs, tremendous interest is oriented toward the therapeutically enhanced personalized healthcare practice. AgNPs proved to have genuine features and impressive potential for the development of novel antimicrobial agents, drug-delivery formulations, detection and diagnosis platforms, biomaterial and medical device coatings, tissue restoration and regeneration materials, complex healthcare condition strategies, and performance-enhanced therapeutic alternatives. Given the impressive biomedical-related potential applications of AgNPs, impressive efforts were undertaken on understanding the intricate mechanisms of their biological interactions and possible toxic effects. Within this review, we focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based nanostructures.

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Section: Silver Nanoparticles For Drug-delivery Systemsmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

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“…The nanoparticles were synthesized according to the protocol reported by Karthik et al 16 Briefly, a solution of chitosan (0.5 g) in 2% acetic acid and silver nitrate (AgNO 3 , 0.5 g) in deionized water were mixed. Exactly above 10 mL of chitosan and silver nitrate solutions were mixed in a boiling tube, and then, the mixture was kept in an autoclave at 120°C for 1 h. Then, the resultant clear orange-yellow solution was mixed with 0.5 g of N-(4chlorophenyl)-4-(2,3-dihydrobenzoĳb]ĳ1,4]dioxine-2-carbonyl)piperazine-1-carbothioamide and sonicated for 3 h at 30°C.…”

Section: Synthesis Ofmentioning

confidence: 99%

Development of piperazine-1-carbothioamide chitosan silver nanoparticles (P1C-Tit*CAgNPs) as a promising anti-inflammatory candidate: a molecular docking validation

Karthik¹,

Manukumar

Sandeep³

et al. 2018

Med. Chem. Commun.

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Natural products are important leads in drug discovery. The search for effective plant-derived agents or their synthetic analogues has continued to be of interest to biologists and chemists for a long time. Herein, we have synthesized a novel compound, P1C, and P1C-Tit*CAgNPs from chitosan; P1C is a precursor and an anti-inflammatory candidate, which has been validated by molecular docking studies. The synthesized P1C-Tit*CAgNPs showed monodisperse, spherical, and cationic nature and antioxidant properties, protecting destabilization of the erythrocyte membrane by the azo compound 2,2'-azobis(2-amidinopropane)dihydrochloride (AAPH); the involvement of NPs as a protective agent for biomolecules, such as DNA and protein, followed by the treatment of NPs with AAPH was confirmed. The inhibition of cellular damage and leakage of cellular inflammatory agents was confirmed by AFM, SEM, TEM, SDS-PAGE, LDH, and PLA2 enzyme inhibition studies. The anti-inflammatory property of P1C was further validated by molecular docking studies and showed that, the P1C best pose aligned to PLA2 compared to standard drug. The significant anticancer property of P1C-Tit*CAgNPs was confirmed against MCF7, U373, and C6 cancer cell lines. Thus, the present study highlights the synthesized P1C in P1C-Tit*CAgNPs as a target PLA2-specific anti-inflammatory candidate, and further tuning of small and development-functionalized nanoparticles has a great future in medicine; hence, their clinical applications are warranted.

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“…Among many metals, synthesizing silver nanoparticle proved its tremendous applications in medicine and industries due to its microbial effect such as antifungal, antibacterial, antiparasitic, and larvicidal properties. Due to its may unrevealed benefits to human, need to process and tune the synthesis and access its properties of silver nanoparticles [14][15][16] including in the field of degenerative disease and cancer biology [17]. Many unrevealed plant components and its characteristics induce focused research scientists to look into that using the antioxidant character as basic property linked to many other properties such as anti-mutagenic, anti-carcinogenic, and anti-allergic [18].…”

Section: Introductionmentioning

confidence: 99%

Biogenic synthesis of silver nanoparticles using Priva cordifolia leaf extract (PC@AgNPs) a potent antioxidant, antibacterial and catalytic activity

et al. 2019

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A nanoparticle preparation (PC@AgNPs), synthesized biogenically using Priva cordifolia leaf extract was found to possess quenching property of stable DPPH and ABTS in dose dependent manner. The PC@AgNPs showed well-established physicochemical stability with respect to temperature, P H and salinity. It showed a broad bactericidal effect against 10 pathogenic bacteria, notably Staphylococcus aureus, Escherichia coli, Shigella flexneri and Vibrio parahaemolyticus. Its non-toxicity up to 500 µg mL −1 concentration to peripheral blood mononuclear cells was recorded. However, its toxic effect against human lung carcinoma cells and human breast adenocarcinoma cell lines at a dose of 500 and 300 µg mL −1 respectively was clearly evident. The catalytic efficiency of PC@AgNPs was demonstrated in methylene blue and methyl orange dye degradation. The studies have suggested possible applications of PC@AgNPs in future biomedical, pharmaceutical, and environmental applications.

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Synthesis of novel benzodioxane midst piperazine moiety decorated chitosan silver nanoparticle against biohazard pathogens and as potential anti-inflammatory candidate: A molecular docking studies

Cited by 48 publications

References 54 publications

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Development of piperazine-1-carbothioamide chitosan silver nanoparticles (P1C-Tit*CAgNPs) as a promising anti-inflammatory candidate: a molecular docking validation

Biogenic synthesis of silver nanoparticles using Priva cordifolia leaf extract (PC@AgNPs) a potent antioxidant, antibacterial and catalytic activity

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