Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

Kurumurthy, C.; Swamy, B. Veera; Kumar, Gopinatha Suresh; Rao, P. Shanthan; Narsaiah, B.; Velatooru, Loka Reddy; Pamanji, R.; Rao, J. Venkateswara

doi:10.1016/j.ejmech.2011.05.011

Cited by 94 publications

(36 citation statements)

References 19 publications

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“…In vitro anticancer [26][27][28][29][30][31][32][33][34][35] activity was determined using a standard MTT assay with protocol appropriate for the individual test system (Abdel-Hafez). In brief, exponentially growing cells were plated in 96-well plates (104 cells/well in 100 µL of medium) and incubated for 24 hrs.…”

Section: In Vitro Anticancer Activitiesmentioning

confidence: 99%

Synthesis, Spectral Characterization and Biological Studies of 2-(4-Methoxynaphthalen-1-Yl)-1-(4-Methoxyphenyl)-1H-Phenanthro[9,10-D] Imidazole

Ramanathan¹

2017

Mod Chem Appl

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Synthesised 2-(4-methoxynaphthalen-1-yl)-1-(4-methoxyphenyl)-1H-phenanthro [9,10-d] imidazole has been characterized by 1 H, 13 C NMR and FT-IR spectral analysis and also biological studies were carried out. The imidazole nitrogen containing heterocyclic ring which possesses biological and pharmaceutical importance. The imidazole ring is ionizable aromatic compound, it improves pharmacokinetic characteristics of imidazole molecules and thus used as a medicine to optimize solubility and bioavailability parameters. There are several methods used for the synthesis of imidazole containing compounds and also their various structure reactions offer enormous scope in the field of medicinal chemistry. The imidazole possesses extensive biological activities such as antimicrobial and anticancer activities.

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Section: In Vitro Anticancer Activitiesmentioning

confidence: 99%

Synthesis, Spectral Characterization and Biological Studies of 2-(4-Methoxynaphthalen-1-Yl)-1-(4-Methoxyphenyl)-1H-Phenanthro[9,10-D] Imidazole

Ramanathan¹

2017

Mod Chem Appl

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13] In addition, pyrido [2,3-d]pyrimidines exhibit antimicrobial, antifungal, and anti-inflammatory activities, [14][15][16] while thieno [2,3-d]pyrimidines exhibit antiproliferative and anti-inflammatory activities. Pyrimidines and their related fused heterocyclic derivatives possess antibacterial, antifungal, antiviral, anti-influenza, antioxidant, anti-inflammatory, antimalarial, antiproliferative, and antitumor activities.…”

Section: Introductionmentioning

confidence: 99%

Efficient synthesis and molecular docking of novel antibacterial pyrimidines and their related fused heterocyclic derivatives

Sanad

Ahmed

Mekky

2019

Journal of Heterocyclic Chem

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3-(Benzo[d] [1,3]dioxol-5-yl)-1-(thiophen-2-yl)prop-2-en-1-one reacted with each of thiourea and 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one to give the corresponding pyrimidine-2(1H)-thiones. Then, these compounds reacted with the appropriate hydrazonyl chlorides in dioxane in the presence of triethylamine to afford the corresponding [1,2,4]triazolo[4,3-a]pyrimidines and their related fused pyridines. Moreover, chalcone was cyclocondensed with 2-cyanothioacetamide to give pyridine-2(1H)-thione and taken as a key synthon to novel 2-(methylthio)pyridothienopyrimidin-4(3H)-one derivative. The above derivative reacted with the appropriate hydrazonyl chlorides in dioxane in the presence of triethylamine to yield the corresponding pyridothieno[3,2-d][1,2,4]triazolo[4,3-a]pyrimidines. Study of the in vitro antimicrobial activities of the newly pyrimidines were performed. Pyridothienopyrimidine 24a showed the highest inhibitory activity against all bacteria with MIC values of 3.9, 7.81, 7.81, and 15.62 μg/mL, respectively, against Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, and Streptococcus mutans, respectively, as compared to reference drugs. Molecular docking was studied to predict of the optimized conformation of pyrimidines as active ligands against the Escherichia coli alkaline phosphatase. The structures of the hybrid molecules were elucidated by IR, Mass, 1 H NMR, and 13 C NMR spectra as well as elemental analyses.

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“…Some compounds containing pyrazolopyrimidine fused ring have been applied in clinical treatment, such as pirenperone used as calmative, Barmastine used as antiallergic agent. Pyrazolopyrimidine compounds are also widely used for killing insects [9], weeding [10], etc. It also has prominent effect in inhibiting dihyrofolate reductase [11] .…”

Section: Introductionmentioning

confidence: 99%

Base-Catalyzed Synthesis of Pyridopyrimidinone Derivatives

Peng¹,

Shi²,

Liu³

et al. 2015

Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials

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Abstract. Nitrogen-containing heterocyclic compounds become main trend of chemical materials gradually due to its structure diversification, high selectivity, low toxicity and other environmentalfriendly characteristics. Meanwhile, it is very important in pharmaceutical research and development. Wherein, people pay more and more attention to pyrazole compounds because of its wide utility, strong efficiency and other features. In the paper, 4-cyano-5-aminopyrazole derivatives 3, synthesized by the condensation of hydrazine and methylene malononitrile, cyclocondensation with aldehyde catalyzed by NaOH to provide pyridopyrimidinone derivatives. The structures of compounds 4 were represented by IR, 1 H NMR, 13 C NMR and MS.

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Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

Cited by 94 publications

References 19 publications

Synthesis, Spectral Characterization and Biological Studies of 2-(4-Methoxynaphthalen-1-Yl)-1-(4-Methoxyphenyl)-1H-Phenanthro[9,10-D] Imidazole

Synthesis, Spectral Characterization and Biological Studies of 2-(4-Methoxynaphthalen-1-Yl)-1-(4-Methoxyphenyl)-1H-Phenanthro[9,10-D] Imidazole

Efficient synthesis and molecular docking of novel antibacterial pyrimidines and their related fused heterocyclic derivatives

Base-Catalyzed Synthesis of Pyridopyrimidinone Derivatives

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