Synthesis of novel 5-methyl pyrazol-3-one derivatives and their in vitro cytotoxic evaluation

Dube, Pritam N.; Bule, Shweta S.; Ushir, Yogesh V.; Kumbhare, Manoj Ramesh; Dighe, Pravin R.

doi:10.1007/s00044-014-1201-z

Cited by 12 publications

(1 citation statement)

References 15 publications

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“…Dube and colleagues [59] synthesized a cluster of pyrazolone heterocyclic derivatives and evaluated their cytotoxic activities in vitro. The results of brine shrimp lethality assay showed that compound 82 displayed a favorable cytotoxic activity than standard cyclophosphamide.…”

Section: C-met Target Inhibitorsmentioning

confidence: 99%

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Zhao

Dai

et al. 2020

European Journal of Medicinal Chemistry

139

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a b s t r a c tThe pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on. Meanwhile, SAR (Structure-Activity Relationship) investigations have drawn attentions among medicinal chemists, along with a plenty of analogues have been derived for multiple targets. In this review, we comprehensively summarize the biological activity and SAR for pyrazolone analogues, wishing to give an overall retrospect and prospect on the pyrazolone derivatives.

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Section: C-met Target Inhibitorsmentioning

confidence: 99%

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Zhao

Dai

et al. 2020

European Journal of Medicinal Chemistry

139

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Iodine‐Promoted Tandem Pyrazole Annulation and C−H Sulfenylation for the Synthesis of C4‐Sulfenylated Pyrazoles

Feng

Wei

et al. 2022

Eur J Org Chem

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Cascade reactions of 1,3‐diarylpropane‐1,3‐dione or unsaturated ketones with arylsulfonyl hydrazide have been achieved in the presence of iodine source. Fully substituted C4‐sulfenylated pyrazoles were synthesized via the tandem pyrazole annulation and C(sp2)−H sulfenylation. This approach is efficient and practical. The starting materials are readily available, while also providing a useful strategy for the construction of different arylthio‐substituted pyrazole skeletons.

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Nanomaterials Causing Cellular Toxicity and Genotoxicity

Şengül

Asmatulu

2021

Nanotoxicology and Nanoecotoxicology Vol. 2

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Synthesis of novel 5-methyl pyrazol-3-one derivatives and their in vitro cytotoxic evaluation

Cited by 12 publications

References 15 publications

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Iodine‐Promoted Tandem Pyrazole Annulation and C−H Sulfenylation for the Synthesis of C4‐Sulfenylated Pyrazoles

Nanomaterials Causing Cellular Toxicity and Genotoxicity

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