Synthesis of Novel 4-Functionalised Oxazolidin-2-ones

Abstract

The synthesis of O-substituted and O-unsubstituted 3-hydroxy-4-thioxo-oxazolidin-2-ones, functionalised 4-imino-oxazolidine-2-ones and 4-phenoxy-imino-oxazolidin-2-one starting from O-substituted and O-unsubstituted 3-hydroxy-4-imino-oxazolidin-2-ones is described. A one-pot protocol for the preparation of 4-methoxyimino-, 4-aralkoxyimino-and 4-phenoxyimino-oxazolidin-2-ones has been developed.

An efficient access to functionally substituted 1,3-oxazolidin-2-ones via cyclization of 1-alkylamino- and 1-arylamino-3-[2-(vinyloxy)ethoxy)]propan-2-ols with dimethyl carbonate

“…drugs for prevention and treatment of heart disorders, antithrombotics 7,8 and anti-tumor remedies, 9,10 antidepressants. 11,12 In addition, the oxazolidin-2-one heterocycles are also used as chiral auxiliaries in asymmetric synthesis. 2,3,13,14 Oxazolidin-2-one-containing polymers possess high heat resistance and thermal stability, high elasticity and improved physico-mechanical properties that allow them to be successfully applied as coatings, lacquers, electrically insulating materials, adhesives, foam plastics and so on.…”