Synthesis of novel 1,3-disubstituted pyrrolo[1,2-a]pyrazine derivatives and antiproliferative effects on glioblastoma cell line

Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5,6-dihydropyrrolo[2″,1″:3′,4′]pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-8(9H)-one Derivatives as Potential Cytotoxic Agents

“…Specifically, the amalgamation of pyrrole with other cyclic structures, notably the fused bicyclic arrangements involving pyrazine or pyridazine, has been extensively explored. This core scaffold has garnered significant attention for the development of novel therapeutics encompassing a diverse spectrum of pharmacological and biological activities. − Particularly, the antiproliferative properties of 1,3-disubstituted pyrrolo­[1,2- a ]­pyrazine derivatives on glioblastoma cell line have been reported by Uygun et al Moreover, Seo et al utilized pyrrolo­[1,2- a ]­pyrazine core to produce 3,4-dihydropyrrolo­[1,2- a ]­pyrazine derivatives and evaluated the anticancer activity of those compounds against prostate cancer (PC3) and breast cancer (MCF-7) cell lines . On the other side, pyrrolopyridazine derivatives have been introduced by their well-known antiviral, anti-inflammatory, and antimicrobial activities .…”