Synthesis of non-ionic surfactants nano-vesicles for clarithromycin oral delivery
Imdad Ali,
Sarzamin Khan,
Samrein Ahmed
et al.
Abstract:In order to improve the solubility and bioavailability of poorly water-soluble drugs, the synthesis of cost-effective nonionic surfactants has been the subject of greater scientific interest. The present study focuses on the synthesis of sulfonyl chloride derivatives as nonionic surfactants (surfactant 1 and surfactant 2) and their evaluation for the preparation of a clarithromycin-loaded niosomal drug delivery system. Surfactants 1 and 2 were characterised by EI-MS and 1H NMR spectroscopy. The shape and size … Show more
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