Synthesis of new thiazole and thiazolyl derivatives of medicinal significant-a short review

Abstract

In the field of therapeutic science, thiazoles are of extraordinary importance, because of their potent and significant biological activities. Likewise thiazole and their derivatives are found in various powerful naturally and biologically active compounds which possess a broad spectrum of biological activity therefore, synthesis of this compound is of remarkable concern. This review primarily focuses on the updated research papers reported in literature for the synthesis of thiazole and thiazolyl compounds.Citation: Hussein W, Zitouni TG. Synthesis of new thiazole and thiazolyl derivatives of medicinal significant-a short review. MOJ Biorg Org Chem. 2018;2(2):52-55.

Synthesis, Characterization and Evaluation of the Antibacterial Activity of Some Heterocyclic Compounds

“…Compound [3] was prepared by adding hydrazine hydrate (10 ml) to (0.008 mol, 2 g) of compound [2] and dissolving it in (20 mL) of the absolute ethanol, and after that, the mix was refluxed for 5 hours. Following the cooling, the precipitate was filtered and then re-crystallized by the ethanol.…”

“…For example, nitrogen-containing heterocyclic compounds have been considered as highly important concepts in pure as well as the applied chemistry. [1][2][3] Ibuprofen, a non-steroidal anti-inf lammatory drug (NSAID), is the gold standard in pain relievers. It is included in the "Essential Medicines List" issue-1d by the World Health Organization (WHO).…”

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This work includes preparing various heterocyclic compound types, which include the phthalazin, pyridazin, pyrazol, phthalazin-3,8-dione [5] and pyridazin-3,6-dione [6] derivatives which derived from hydrazide compound [3]. The structures of those compounds have been identified by the fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance ( 1 H-NMR) spectroscopy and checked with the use of the TLC technique, and evaluated the antibacterial activities for some of the synthesized compounds.

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Synthesis and Antimicrobial Study of Thiophene Clubbed Thiazolyl Carbohydrazides

“…Acid hydrazides can be synthesized from esters 20,21 . Although thiazole and substituted thiazoles can be synthesized by various routes [22][23][24][25] , Hantzsch synthesis [26][27][28] is an efficient and widely preferred route of thiazole synthesis. Phenacyl bromides are widely used in thiazole synthesis 29 .…”

New thiazole, pyridine and pyrazole derivatives as antioxidant candidates: synthesis, DFT calculations and molecular docking study

“…Heterocyclic compounds show best interests in this subject, such as 1,3-thiazole, which is one of the important five-membered rings containingnitrogen and sulfur as heteroatoms (Nayak and Gaonkar, 2019). It's a known scaffold as a potential pharmacophore in many biological activities (Abdel-sattar and El-naggar, 2017;Hussein and Turan, 2018;Lettre et al, 2010;Scarim et al, 2019;Varghese et al, 2016;Yadav and Senthilkumar, 2011). In addition, pyrazole, which is a five-membered heterocyclic ring containing two adjacent nitrogen, can be found in many industrial fields (Chauhan et al, 2011;Karrouchi et al, 2018;Khan et al, 2016;Yerragunta et al, 2014).…”